Studentshare
Subjects
Science
Genotyping to Identify the Candidate Genes of Type 2 Diabetes

Genotyping to Identify the Candidate Genes of Type 2 Diabetes - Literature review Example

Summary

This literature review “Genotyping to Identify the Candidate Genes of Type 2 Diabetes” reflects upon sources representing the latest scientific advances in the study of hereditary and environmental factors predisposing to the occurrence of type 2 diabetes…

Download full paper File format: .doc, available for editing

GRAB THE BEST PAPER98.6% of users find it useful

Genotyping to Identify the Candidate Genes of Type 2 Diabetes

Read Text Preview

Subject: Science
Type: Literature review
Level: Ph.D.
Pages: 25 (6250 words)
Downloads: 2
Author: mbruen

Extract of sample "Genotyping to Identify the Candidate Genes of Type 2 Diabetes"

Download file to see previous pages

A discussed sample was genotyped on an Affymetrix 100K SNP (Single Nucleotide Polymorphism) array and was tested for connection with incident diabetes and 6 quantitative traits associated with diabetes. The replication sample comprised of 1,465 discrete FHS offspring which was drawn from a plated set of DNAs where only a single person from individual pedigree was selected. An added sample of 251 offspring which were also genotyped and examined in the 100K array helped to test the degree of concordance between the 100K GWA scan and follow-up genotyping platforms.

The quality control filters generated 66543 SNPs for the investigation process. Two methods were used to prioritize SNPs that are strongly associated with type 2 diabetes or allied traits. The first strategy used the ranking of P values derived from GEE or FBAT models and chose those SNPs with P<0.01. The other strategy chose SNPs allied with multiply related traits. The 763 SNPs prioritized were analyzed for in silico reproduction in 3 other 100K and a 500K GWA datasets. The statistical analysis for quantitative traits employed the GEE and FBAT models to examine the correlation between age and alleles.

The incident Type II diabetes was tested through the Cox Model which examined the hazard ratio with respect to SNPs against the risk of new diabetes cases. Martingale residuals tested from a sex-adjusted model that showed high negative value implying early onset of diabetes and high positive value implying no diabetes at a later stage with follow-up. The results showed that the 100k scans gave no credible in silico replication. 78 SNPs showed association with traits related to diabetes in the 100K GWA scan and 25 showed the same in 500K GWA analysis.

The FHS 100K GWA scan is a valuable tool for follow-up of genetic correlations with diabetes-linked quantitative traits. To find out new diabetes genes, one would need bigger samples and a denser array along with potential replication strategies.

...Download file to see next pages Read More

Cite this document

APA
MLA
CHICAGO

(Genotyping to Identify the Candidate Genes of Type 2 Diabetes Literature review, n.d.)
Genotyping to Identify the Candidate Genes of Type 2 Diabetes Literature review. Retrieved from https://studentshare.org/science/1732588-gwas

(Genotyping to Identify the Candidate Genes of Type 2 Diabetes Literature Review)
Genotyping to Identify the Candidate Genes of Type 2 Diabetes Literature Review. https://studentshare.org/science/1732588-gwas.

“Genotyping to Identify the Candidate Genes of Type 2 Diabetes Literature Review”, n.d. https://studentshare.org/science/1732588-gwas.

Cited: 0 times

CHECK THESE SAMPLES OF Genotyping to Identify the Candidate Genes of Type 2 Diabetes

Prevention of Diabetes

There is also a predominant abnormality during the early stages of type 2 diabetes.... There is also a predominant abnormality during the early stages of type 2 diabetes.... There is also the type 2 diabetes.... There is also the type 2 diabetes.... On the other hand, about 20%-50% of women who have suffered gestational diabetes get type 2 diabetes in later life.... Another type of diabetes that has a close resemblance to type 2 is gestational diabetes....

4 Pages (1000 words) Research Paper

Biology of Diabetes

The type 2 diabetes is a more common form of the disease which manifests only in adulthood when the islet cells begin to secrete less amounts of insulin or the body does not respond well to the secreted insulin.... The genes associated with type 2 diabetes are those which are involved in pancreatic beta-cell function, insulin action, metabolism of glucose and other conditions such as lipid metabolism and energy uptake and release.... Some of the candidate genes for the disease include PPAR?...

5 Pages (1250 words) Research Paper

Gene Type: BRCA1

hellip; This gene produce proteins referred to as Breast Cancer type 1 found in breast cells and other tissues of the human body (Kadouri & Rotenberg 468).... BRCA1 is a gene that belongs to a group of genes called Tumor suppressors.... BRCA1 is a gene that belongs to a group of genes called Tumor suppressors.... These two human genes belong to a group of genes called tumor suppressors.... Ovarian cancer and heredity breast normally arises from mutation of these two genes....

3 Pages (750 words) Research Paper

Mismatch Repair Genes and Cancer

The MMR genes tested in the investigation included the mismatch repair genes of the MSH family, as well as that of the MLH family.... One type of mutation that was tested for was the loss of heterozygosity, which is a type of mutation that generates a change in the type of genetic transmission of cells.... The other type of mutation that was screened in the study was microsatellite instability.... This type of mutation is known as a synonymous mutation....

2 Pages (500 words) Essay

Type 2 Diabetes in a Subpopulation of Saudi Arabian Women

The most important environmental risk factor is obesity; however, this is not the only determinant of population or individual… Genetic predisposition for the disorder is also a contributing factor, and decreased susceptibility to the development of type 2 diabetes may be correlated with certain genotypic factors.... A subpopulation of Saudi Arabian women has been identified that is resistant to the development of type 2 diabetes, despite incidence rates of obesity at the same level as the entire population of women in Saudi Arabia....

4 Pages (1000 words) Essay

Instructional Maual on chidren with diabetes

These include type 2 diabetes, type 1 diabetes and gestation diabetes.... In type 2 diabetes, body cells fail to react with insulin.... Children with diabetes experience frequent urination (polyuria), quick hunger… There are three types of diabetes.... In type 1 diabetes, the body of the patient fails to produce adequate insulin (Hanas, 2004, p.... People develop this type of Patients suffering from type 1 diabetes are forced to take insulin injections throughout their lives....

4 Pages (1000 words) Essay

Diabetes type 2 treatment and prevention

type 2 diabetes mellitus has become a worldwide problem that has affected the economy of many countries.... et al (2013) says that in the modern society, people tend to practice unhealthy lifestyle, such as eating fast foods, taking soft drinks and energy snacks; they also engage themselves in sedentary lifestyles and tend to spend most of their time on electronic… This trend has resulted in people becoming overweight and obese, thus predisposing them to diabetes type 2....

3 Pages (750 words) Research Paper

"An exploration of genes, inheritance and gene therapy for diabetes"

The sugar level in the blood increases because of the insufficient production of the insulin, or the cells of the body do not act in return… diabetes is divided into two types namely type one and type two. Whether diabetes can be inherited genetically or not is not clear but it is thought that a person becomes a victim of this disease when he inherits a predisposition to the disease from his parents.... Cell transplantation is more successful treatment for diabetes as compared to the method of using insulin injections....

6 Pages (1500 words) Essay