Nobody downloaded yet

Gene Type: BRCA1 - Research Paper Example

Comments (0) Cite this document
BRCA1 is a gene that belongs to a group of genes called Tumor suppressors. BRCA1 is responsible for providing instructions used in repairing defective or damaged DNA through Non-homologous End Joining (NHEJ)…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER92.2% of users find it useful
Gene Type: BRCA1
Read TextPreview

Extract of sample
"Gene Type: BRCA1"

Download file to see previous pages BRCA1 is a gene that belongs to a group of genes called Tumor suppressors. BRCA1 is responsible for providing instructions used in repairing defective or damaged DNA through Non-homologous End Joining (NHEJ). Since double helix strands of DNA undergo continuous breakage, it is the function of BRCA1 proteins to repair broken strands. BRCA1 proteins restore broken strands of DNA by utilizing homologous sequences from either sister chromatid or from same chromosome. Repair process of DNA entails wrapping of cell nucleus around histone to form histone-DNA complex. In cell nucleus, BRCA1 proteins normally combine with RAD51 in maintaining stability of human genome by repairing broken strands of DNA. Another function of BRCA1 proteins is that it inhibits nuclease activity of MRN complex and Mre 11 by possessing high affinity for the branched structures of DNA. As a result, BRCA1 gene promotes high fidelity for DNA repair using NHEJ. BRAC1 and BRAC2 BRAC1 refers to Breast Cancer Susceptibility gene 1 while BRAC2 stands for Breast Cancer Susceptibility Gene 2 (Malone, Daling & Doody 8299). These two human genes belong to a group of genes called tumor suppressors. Ovarian cancer and heredity breast normally arises from mutation of these two genes. When a woman inherits destructive BRAC1 or BRAC2 during mutation, she stands a high risk of developing ovarian or breast cancer. However, men also have stands elevated risks of suffering from breast cancer when mutation of these two genes takes place in their bodies. In normal human cells, BRAC1 and BRAC2 ensure that genetic material or DNA is stable. In addition, these two genes are responsible for preventing any uncontrolled growth of cells in human body (Malone, Daling & Doody 8299). Effects of Mutation When an individual is born with a particular mutation or experiences mutations in the entire lifetime, a number of changes occur in the bodies of these individuals. Some mutations are deleterious or harmful while some gene changes are beneficial. In harmful mutations, an individual is likely to suffer from various diseases such as cancer. For instance, a woman stands a lifetime risk of developing ovarian or breast cancer during harmful mutation of BRAC1 and BRAC2. In BRAC1, mutation increases the risk of contracting uterine, cervical, colon, and pancreatic cancer I women. However, mutation of BRAC1 in men causes testicular, pancreatic and prostate cancer. Individuals with family history of mutations especially BRAC1 and BRAC2 stand high chances of contracting tumors or cancer. This is because family members normally share same genes and environment. From research conducted in individuals experiencing various mutations, it is evident that most mutations are hereditary (Vogel & Erlichman 4638). Gene Location In terms of molecular level, BRCA1 gene is located in a chromosome called 17q21. The process of identifying location of the gene on the chromosome entails the use of Simple Sequence Repeat (SSR) markers on chromosome 17, which constructed a genetic map that had very high resolution. ABI sequencing is responsible for capturing genotypes from the five SSR markers (Kadouri & Rotenberg 468) Difference between Mutation and Normal Genes Women experiencing mutation of BRCA1 gene tends to have high levels of oestrogen that stimulates uncontrolled growth of cells or breast tissue. However, normal BRCA1 genes can control increase of breast cells and tissues in human body. In addition, normal genes have the capability of stabilizing DNA cells while preventing any uncontrolled growth of cells. Mutation genes do not have the ability of repairing any broken strands of DNA. Lastly, normal gene does not result in any ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Gene Type: BRCA1 Research Paper Example | Topics and Well Written Essays - 750 words”, n.d.)
Gene Type: BRCA1 Research Paper Example | Topics and Well Written Essays - 750 words. Retrieved from https://studentshare.org/biology/1480147-gene-type-brca1
(Gene Type: BRCA1 Research Paper Example | Topics and Well Written Essays - 750 Words)
Gene Type: BRCA1 Research Paper Example | Topics and Well Written Essays - 750 Words. https://studentshare.org/biology/1480147-gene-type-brca1.
“Gene Type: BRCA1 Research Paper Example | Topics and Well Written Essays - 750 Words”, n.d. https://studentshare.org/biology/1480147-gene-type-brca1.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Gene Therapy
The genes thus introduced exert their benefits by either compensating for the abnormal genes or by producing beneficial protein or by supplementing the abnormal gene (Hecht, n. p.). The first gene therapy clinical trial started in 1990 (Verma and Weitzman, n.
3 Pages(750 words)Research Paper
Breast and Ovarian Cancer
In United States, next to non-melanoma skin cancer, breast cancer remains the most prevalent cancer in women and the major cause of death due to cancer. According to latest data facilitated by the U. S. Cancer Statistics Working Group, in the year 2007 the number of women in U.
7 Pages(1750 words)Research Paper
Continuous type
There is also an in depth discussion on how the sensor is used and the advantages and disadvantages of the sensor in an industrial setting. Given the role played by the sensors, it was also important that the mechanism of operation of the sensor is discussed.
3 Pages(750 words)Research Paper
eotide sequence that can possibly produce such oligopeptide, the sequences upstream and downstream of it will be used to identify sequences compatible with restriction enzyme digestion. Upon treatment of the purified mouse DNA with restriction enzymes, the isolated DNA
8 Pages(2000 words)Essay
A single gene disorder
Databases suggest that there are more than 6000 known single gene disorders with an autosomal dominant or recessive or a X-linked inheritance pattern (Human Genome Project Information, 2008). One such single
4 Pages(1000 words)Research Paper
Induction of Gene Expression
The lac operon is a cluster of three genes, lacZ, lacY and lac A, which are structural genes that code for - galactosidase, galactoside permease and - galactoside transacetylase respectively. These three genes are involved in the uptake and metabolism of lactose.
5 Pages(1250 words)Research Paper
Diabetes Melllitus Type II
Diabetes could also be seen due to decreased ratio of insulin/anti-insulin hormones. More often than not, diabetes is accompanied with secondary changes in metabolism of protein, lipids, water and electrolytes
6 Pages(1500 words)Research Paper
Gene Therapy
The commonest gene therapy involves substituting a mutated gene (that is causing disease) with a new functional gene obtained
5 Pages(1250 words)Research Paper
Gene Therapy Research Paper
It is important to note that gene therapy is still an experimental approach to therapy. Therefore, a lot of further research is required before the full potential of this form of therapy can be realized (Bryant, Duker and Reichel 89). The history of gene therapy and the related concepts can be traced to the 1960s and early in the 1970s.
8 Pages(2000 words)Research Paper
Type I Diabetes
Homeostatic balance is controlled by hormones and enzymes respectively. Any variation in the level of these chemicals leads to homeostatic imbalance. Diabetes mellitus type 1 is an example of a condition which results from an altered level of insulin in the body.
6 Pages(1500 words)Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Research Paper on topic Gene Type: BRCA1 for FREE!
logo footer
Contact us:
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us