Efficacy of Various Uses of Loratadine - Essay Example

Loratadine Literature Analysis Scores Strength Method Main result Level of evidence criteria Methodology Result Overall Score Allergy Rhinitis 1 Compare efficacy, safety, and impact on the quality of life of fluticasone propionate aqueous nasal spray (FP ANS), loratadine, FP ANS plus loratadine, and placebo in treating seasonal allergic rhinitis Ratner PH, Van Bavel JH, Martin BG, et al. J Fam Pract 1998;47:118–125 FP ANS 200mcg once a day, or loratadine 10mg, once a day, or FP ANS and loratadine regimens combined; and placebo 600 participants randomized, double-blind study -Overall evaluations significantly lower in the FP ANS and FP ANS plus Ioratadine groups compared with the Ioratadine only and placebo groups. Loratadine not statistically different from placebo in clinician and patient symptom score ratings nor in overall clinician and patient evaluations. FP ANS plus Ioratadine and FP ANS monotherapy comparable in efficacy 1.2. Compare the efficacy, safety and impact of quality of life in seasonal allergic rhinitis patients after treatment with either fexofenadine and loratadine Van Cauwenberge P, Juniper EF, Albegger Almeida M, et al, Clin Exp Allergy 2000;30:891–899 Fexofenadine, 120 mg; loratadine 10 mg; and placebo 688, randomized, double-blinded TSS significantly reduced by both fexofenadine HCl (both P Read More