My meeting with Jane was quite distressing as I observed this 65-year old woman sitting silent, with not much of reaction towards what was happening in her surroundings. At first she looked at me, stared for a few seconds, and continued to look out of the window by her bedside…
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I was told that she was suffering with Alzheimer’s disease, a condition very often found in people above 60. This is a neurological disorder leading to dementia, and most commonly described as loss of mental abilities such as memory and reasoning. With its progressive nature, it manifests as slight memory and language problems in the beginning and further leading to confusion, personality and behavioral changes. Thus, this disease manifests in the form of cognitive and behavioral symptoms.
The most common clinical findings in this disease include loss of recent memory, problems in calculation and execution of activities. These difficulties eventually progress to dementia in a span of eight to nine years. Motor functions may get impaired in the terminal stages of the disease causing inability to walk or move. The pathological precursors of this disease begin several decades before the clinical symptoms are manifested. The most important characteristic features of this disease, as described by Alois Alzheimer in 1907, are neuronal loss, profuse extracellular deposition of amyloid B peptide (AB), and widespread formation of intraneuronal neurofibrillary tangles, usually found in the higher order cortical regions including frontal, parietal, and temporal cortex and the limbic system, and are relatively rare in primary motor or sensory areas except for olfaction. For this reason, Alzheimers disease is looked at more like a cognitive disorder than motor one (Rogers, J.; 2001). However, the reasons for neurodegeneration are still unknown.
Alzheimers disease, like most other chronic diseases, is likely to be caused by a complex interaction of genetic and environmental risk factors. A few definite risk factors associated with Alzheimer’s disease, identified by Kuhn and Bennett (2003), are advanced age, family history in firs-degree blood relation, genetics, Down’s syndrome, history of head trauma, and low
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(“Alzheimers Essay Example | Topics and Well Written Essays - 2000 words”, n.d.)
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(Alzheimers Essay Example | Topics and Well Written Essays - 2000 Words)
“Alzheimers Essay Example | Topics and Well Written Essays - 2000 Words”, n.d. https://studentshare.org/miscellaneous/1561532-alzheimers.
The aging population in the United States has been improving with the result in the greater number of people suffering from age related pathologies.Dementia is one of the most important diseases of the elderly.Dementia is sometimes confused with Alzheimer’s disease.
AD is a neurodegenerative disease that starts in the temporal lobe leading to memory deficits (Alafuzoff et al., 2008). The pathology soon spreads to other parts of the brain leading to dementia. Dementia is the loss of cognitive abilities in various domains, leading to impairment in activities of daily living and the loss of independence (American Psychiatric Association [DSM-IV-TR], 2000).
It is estimated that the annual total cost of caring for a single AD patient in an advanced stage of the diseases is greater than $50,000 (Fauci et.al, 2008).
In Alzheimer's Disease, there is severe progressive deterioration in mental functions with a subtle, insidious onset.
All these problems do not affect person's capacity to hear and recognize new information, understand the meaning of the words addresses to this person, analyze the information, and carry out daily chores, as it happens with those who are from Alzheimer 's disease.
Some of the proteins help in recognizing the signals and sorting out the cargo proteins. Among these proteins are: AP-1, AP-2, AP-3 and AP-4. AP-1 has been further divided in AP-1A and AP-1B. The existing evidence provides association among APP, MDCK cells and Tyr653; these are related during the process of transportation of APP to basolateral domain of MDCK cells.
Researchers and doctors use a number of scales to measure the progression of symptoms over time, which may define as many as seven distinct stages of the disease. There are three broad phases which are typically recognized, they are: mild (confusion and memory loss), moderate (difficulty with activities of daily living) and severe symptoms (loss of speech).
Drugs have not been successful because “the drugs were tested too late in the progression of the disease (Singer, 2010).” This paper will give a summary of the article ‘How Brain Imaging Could Help Predict Alzheimer’s.’ It looks at the potential of
precisely to let members of the medical profession observe its rules at all times and avoid all the sticky situations presented by possible conflicts of interest while in the exercise of their duties. A classic dilemma faced by medical practitioners is whether to tell the bad
Alzheimer’s is a form of dementia that affects people’s memory, thinking, and behaviors (“What Is Alzheimer’s?”). Though Alzheimer’s commonly affects people who are 65 years old and above, it does not represent a normal stage of aging, nor does it affect
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