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Human beings are dependent on the sun exposure to fulfill their needs of vitamin D. It is uv-B radiation that are being absorbed by 7-dehydrocholesterol present in the skin that aids in…
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Download file to see previous pages ll age groups; during infant to childhood stage it plays an essential role in bone development or else its deficiency results in bone deformation and rickets. In adults its deficiency results in softness of bone leading to osteomalacia. (Goldman, 2004).
Vitamin D3 once formed goes into circulation and is converted to 25 hydroxyvitamin D3 in liver, again released in circulation and subsequently converted to the active form of vitamin D, 1, 25- dihydroxyvitamin D3 in kidney. It is observed that Vitamin D deficiency remains unrecognized and therefore its insufficiency is taking a shape of epidemic among children and adults in United States.
Various research studies have been carried out throughout the world to conclude that vitamin D plays an imperative role not only for the bone health but also for various kinds of cancers, diseases related to heart, multiple sclerosis, in type I diabetes, also in various autoimmune diseases encompassing rheumatoid arthritis. Therefore, maintenance of suitable blood concentration of 25-hydroxyvitamin D (30 ng/ml) is very essential. As vitamin D is essential for enhancing intestinal calcium absorption, it’s appropriate level in the blood is also necessary for the formation of extrarenal 1α- hydroxylase which plays an imperative role in the formation of 1, 25- dihydroxyvitamin D3 (Holick, 2004).
When an individual is exposed to sunlight previtamin D3 and also vitamin D3 forms photoproducts which are biologically inert. Vitamin D intake through diet or that formed in the skin with the help of sunlight come into the blood circulation, it reaches liver where it is metabolised to 25(OH)D3 by vitamin D 25-hydroxylase (25-OHase). 25(OH)D3 is again released in the circulation, it reaches kidney and get converted to 1,25(OH)2D3 in presence of enzyme 25(OH)D3 1-hydroxylase (1-OHase). The renal production of active form of vitamin D is regulated by a variety of features encompassing serum phosphorus (Pi) and PTH. The active form of ...Download file to see next pagesRead More
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