Research of Dissertation Problem Statements - Essay Example

The patients were selected on the basis of their and birth weight and the diagnosis of RDS of prematu­rity. There is no reference in the work regarding the randomization of the treatments. However the statement that all the neonatal who suffered from RDS were treated with the new ventilatory strategy for 24 months points towards a wide range of population. All the 72 patients included in the study were properly accounted for at the conclusion of the trial as data on gestational age, birth weight gender, incidence of prenatal steroid treatment, low Apgar score at 1 and 5 minutes, and severity of RDS of prematurity were recorded and analysed in the case of all the 72 patients.

There is no reference to the homogeneity of the group in the trial. However as the basic differences on gestational age, birth weight gender, incidence of prenatal steroid treatment, low Apgar score at 1 and 5 minutes, and severity of RDS were accounted for as variables in the study and thus wont affect the precision of the result. The trial addressed a clearly focused issue that whether the improved pulmonary out­come and less lung injury persisted (outcome) in the infants who had respiratory distress syndrome(population) and were exposed to high-frequency oscillatory ventilation (HFOV) in comparison with the infants exposed to conventional ventilation (CV) (intervention).

The trial was a follow up design of a previous multicenter controlled clinical trial in which surfac­tant-heated premature newborns with moderate to se­vere respiratory distress syndrome were randomly assigned to early treatment with high-frequency oscillatory ventilation (HFOV) or to conventional ventilation (CV). Compared with control infants who were treated with CV, neonates who were treated with HFOV using a strategy designed to recruit and maintain lung volume and