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Dopamine and its Role in Parkinsons Disease...Dopamine and its Role in Parkinson’s Disease Parkinson’s disease (PD) is a chronic disease that debilitates an individual over time. Beyond the physical issues for PD there are also mental and emotional challenges. Central to these other issues is depression, dementia, psychosis and personality disorders. Depression is one of the most prominent of the disorders with 45% of people with PD experiencing it (Lemke 9).
In the article, “Dopamine Agonists in the Treatment of Non-Motor Symptoms of Parkinson’s Disease: Depression” by M.R. Lemke, a better understanding of how dopamine works in PD is presented.
1 Dopamine and...
8 Pages(2000 words)Research Paper
Parkinsons Desease.... Of the most gruesome challenges has been the Parkinson’s disease that has proven to be a leading setback to the members of the society. The disease has been noted as the second most neurodegenerative ailment that affects the societal members. The repercussions of the condition have advanced the prospects in limiting effective sustenance of the physical condition and the desire to complete activities. The condition has limited the prevalence of the healthy condition within the society as the health organization and practitioners seek to adjust the society to accommodate the changes realized in the condition. Although a challenging medical condition among the members of the society, the...
9 Pages(2250 words)Research Paper
Parkinsons Disease... Parkinson’s disease IMPORTANCE, AND BACKGROUND INFORMATION In the contemporary society, quality healthcare has become the center of debate as a measure towards better social welfare of the people. The emergence of various physical and psychological disorders is at an alarming rate and one of such conditions in this case is Parkinson’s disease. As a person ages, various forms of physical challenges begin to set in and in most cases this tends to make them begin undergoing a mental degradation. Parkinson’s disease comes second among the most common neurodegenerative disorders with the greatest effect in movement. Its discovery can be traced back to 5000 BC but a vivid description of the condition was given by James Parkinson who... old and to...
4 Pages(1000 words)Research Paper
Mitochondrial DNA...Mitochondrial Deoxyribonucleic acid, mtDNA, is found within the cell's mitochondria. Contradictory to most of the cell, the function of which is defined by nuclear DNA, mitochondria have their own DNA; and it is assumed to have evolved separately. This DNA is unique because it is inherited maternally, and only maternally, which allows researchers to trace lineage far back in time (Lyle 2004). Mitochondrial Eve is the name given by researchers to a female that is the most recent common matrilineal ancestor of all living humans. Eve is known due to mitochondrial DNA, and the comparison of DNA sequences from mtDNA reveals a phylogeny. Mitochondrial Eve is thought to have...
3 Pages(750 words)Essay
Fatigue and Limbic Dysfunction in Parkinsons Disease.... In essence, I did the best I could with what I was provided.
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Introduction: Summary of Purpose and Thesis
Parkinson's disease (PD), first described by James Parkinson in 1817 (Figure 1), is one of the most prevalent disabling illnesses that can occur later in life. It is estimated to affect 1% of 70-year-olds, but is also seen in younger people, with 10% of cases occurring before the age of 50.
The disease has become the pathfinder for other neurodegenerative disorders, since discovery of dopamine deficiency within the basal ganglia led to the development of the first effective treatment for a progressive...
10 Pages(2500 words)Essay
Parkinsons Disease...A. Hause and Theresa A. Zesiewicz, Advances in the Pharmacologic Management of Early Parkinson Disease. The Neurologist 2007;13:126-2.
38. Olanow CW, Obeso JA, Stocchi F. Continuous dopamine-receptor treatment of Parkinson's disease: scientific rationale and clinical implications. Lancet Neurol. 2006;5:677- 7.
39. Knoll J. Deprenyl (selegiline): the history of its development and pharmacological action. Acta Neurol Scand. 1983;95:57- 0.
40. Youdim MBH, Gross A, Finberg JPM. Rasagiline _N-propargyl-1R(+)-aminoindan, a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001;132:500 -6.
41. Robert A. Hauser, and Theresa A....
8 Pages(2000 words)Essay
Parkinsons disease...Market Analysis of Parkinson’s disease Introduction Parkinsons disease or PD is a persistent neurodegenerative disorder leading towards major abnormality that deteriorates quality of life of the sufferer to a great extent. (Lau, 234) After Alzheimer’s disease it is the second most prevailing neurodegenerative disease (Nussbaum and C.E. Ellis, 210) which causes a huge burden on the sufferer himself, his carers, family and the over all medical systems (Rubenstein, 305)
Market Characteristics
Its occurrence is seen in less than 50 years of age one out of seven patients, and the occurrence increases with the increase in age. At the moment...
4 Pages(1000 words)Essay
Parkinsons Disease...PARKINSON DISEASE EPIDEMIOLOGY and AETIOLOGY In today’s society, the prevalence and incidence of Parkinson’s disease continue to increase affectingboth males and females as the population ages. Stephen and company in their study (2003) pointed out that the rapid increase of incidence is over 60 years old with a small percentage of cases under 50. They further found out that its incidence varies by race and ethnicity. Throughout the world, it is estimated that about millions are affected. The disease is a slow degenerative disorder of the central nervous system impairing cognitive, motor and other bodily functions (Tortora 2008). Despite many studies conducted about the disease, the cause of it is unknown. However, it is known... is being...
7 Pages(1750 words)Essay
Parkinsons Disease: New Treatments...Parkinson’s disease Parkinson’s disease, also known as shaking palsy is one of the most common neural and movement disorder. It leads to loss of muscles and their control, so that in its progressive stages, even simple tasks become difficult or impossible to execute. The usual age of victims of this disease are sixty and above, and this trend is to change as people live for longer now. (Heyn)
The brain’s nerve cells produce a chemical called dopamine which helps send messages to and fro in the body and controls movement of muscles. This disease attacks those dopamine producing nerve cells. Since messages cannot be communicated, messages cannot be sent and functioning of the muscles is not proper and eventually there is a loss... of...
3 Pages(750 words)Essay
Mitochondrial Uncouplers...Mitochondrial Uncouplers Using your knowledge of the processes of cellular respiration, describe the effect of 2,4-dinitrophenol on oxidative phosphorylation. (2.5 points)
Cellular respiration involves formation of ATP from, addition of a phosphate molecule to ADP, oxidative phosphorylation. During the process of oxidative phosphorylation, there is a transfer of electrons from NADH to O2. The transfer of electrons results to the pumping out of protons which are responsible for the formation of ATP through creation of a proton-motive force(El-Zanfaly and Marwa 208). Unfortunately, 2,4-dinitrophenol increases basal leak of these protons (H+), and as a result affect the oxidative phosphorylation process.
2. Why does...
1 Pages(250 words)Essay