We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Nobody downloaded yet

MPTP and Its Role in Toxic Parkinsonism - Essay Example

Comments (0) Cite this document
Summary to essay on topic "MPTP and Its Role in Toxic Parkinsonism"
Mohammed Ali, Pope John Paul II, Michael J. Fox. These three men who are known and respected in the fields of boxing, religion and show business, respectively seem to have nothing in common. To the common people, they seem to be worlds apart in their way of life, from their beliefs to their everyday dealings, yet, all of them share a common ground: Parkinson's Disease.
Download full paper
Polish This Essay
MPTP and Its Role in Toxic Parkinsonism
Read TextPreview

Extract of essay "MPTP and Its Role in Toxic Parkinsonism"

Download file "MPTP and Its Role in Toxic Parkinsonism" to see previous pages... The degeneration of the substantia nigra of the basal ganglia coupled with intracytoplasmic inclusions known as Lewy bodies is the pathological characteristic seen in patients afflicted with PD. "The primary biochemical defect is the loss of striatal dopamine" which is the neurotransmitter produced by the neurons in the pars compacta of the substantia nigra (Braddom,
Let us write or edit the essay on your topic "MPTP and Its Role in Toxic Parkinsonism" with a personal 20% discount.. Try it now
1164). The basal ganglia "assist in the regulation of voluntary movement and the learning of motor skills" (Snell, 320). It also functions in the initiation of movements. It is because of this that patients present primarily
with motor affectations with the cardinal signs for PD which include bradykinesia (characterized by a slowness and sudden pause in movement), resting tremors (uncontrolled shaking or movement), muscular rigidity (stiffness) and postural instability.
The specific cause for Parkinson's disease is still unknown. Genetic factors such as defects in or mutations of several genes are known to cause PD, but these mutations actually result in only a very small number of cases of PD, in as little as 5% of the total number of PD cases. The two most important genes are "called parkin (autosomal recessive) and LRRK2 (autosomal dominant). Other genes that, when mutated, are known to cause PD include alpha-synuclein, DJ-1, PINK-1, and UCHL-1" (American Parkinson Disease Association). Envirionmental factors, such as exposure to toxins like pesticides/herbicides, industrial chemicals, trace metals, cyanide and carbon monoxide, are also thought to be a likely cause of Parkinson's Disease. 'The most compelling evidence for an environmental factor in PD relates to the toxin 1,2,3,6-methyl-phenyl-tetrahydropyridine (MPTP)" (Olanow & Tatton, 124). In the late 1940's, MPTP was first tested for its possible therapeutic use tested as a possible anti-parkinsonian agent. Conversely, the drug was abandoned soon after the 6 humans given the drug developed PD symptoms and 2 of them died (myDr.com). The surge in the numbers of the MPTP-induced Parkinsonism came in the 1980's when it was being sold in the streets as synthetic heroin. The case study done by (Ballard, Tetrud & Langston, 949) wherein the subjects, seven patients in total, developed permanent chronic and severe parkinsonism after repeatedly injecting MPTP intravenously. MPTP is able to cross the blood-brain barrier and react with the enzyme monoamine oxidase (MAO) (Hauser et.al). The interactions of MPTP with monoamine oxidase (MAO) was studied by Singer, Salach, Castagnoli & Trevort in 1986. (785)
(Last Name) 3
l-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a thermal breakdown product of a meperidine-like narcotic. The nigrostriatal toxicity is not due to MPTP itself but to one or amore oxidation products resulting from the action of monoamine oxidase (MAO) on this tertiary allylamine. Both MAO A and B catalyse the oxidation of MPTP to the 1-methyl-4-phenyl-2,3-dihydropyridinium species (MPDP+), which undergoes further oxidation to the fully aromatic 1-methyl-4-phenylpyridinium species (MPP+). These bio-oxidations are blocked by selective inhibitors of MAO A ...Download file "MPTP and Its Role in Toxic Parkinsonism" to see next pagesRead More
Cite this document "MPTP and Its Role in Toxic Parkinsonism"
  • APA
  • MLA
(“MPTP and Its Role in Toxic Parkinsonism Essay Example | Topics and Well Written Essays - 1000 words”, n.d.)
MPTP and Its Role in Toxic Parkinsonism Essay Example | Topics and Well Written Essays - 1000 words. Retrieved from https://studentshare.org/miscellaneous/1509458-mptp-and-its-role-in-toxic-parkinsonism
(MPTP and Its Role in Toxic Parkinsonism Essay Example | Topics and Well Written Essays - 1000 Words)
MPTP and Its Role in Toxic Parkinsonism Essay Example | Topics and Well Written Essays - 1000 Words. https://studentshare.org/miscellaneous/1509458-mptp-and-its-role-in-toxic-parkinsonism.
“MPTP and Its Role in Toxic Parkinsonism Essay Example | Topics and Well Written Essays - 1000 Words”, n.d. https://studentshare.org/miscellaneous/1509458-mptp-and-its-role-in-toxic-parkinsonism.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Operations management and its role
It is briefed that the main role of adopting operations management strategies is to ensure that business operates efficiently by using minimal resources to satisfy customer’s needs and expectations.
6 Pages(1500 words)Essay
Ecosystem Toxic Chemical Threat
By definition, heavy metals have a density of 5.0/gcm3 or more which is much heavier than the density of an average soil particle. They occur naturally in rocks but their concentrations are regularly augmented due to contamination and pollution. The most common heavy metals with respect to possible hazards are mercury, lead and cadmium and chromium.
5 Pages(1250 words)Essay
Ecosystem Toxic Chemical Threat
According to World Meteorological Organization, there was almost a 30% increase in the Earth’s atmosphere in a span of two decades. It is important to discuss this greenhouse gases and its environmental effects as most anthropomorphic activities produce these gases.
5 Pages(1250 words)Essay
Parkinsons Disease
Parkinsons disease (PD) is a common progressive neurodegenerative disorder that is characterized by the loss of striatal dopamine (DA) as a result of degeneration of dopaminergic (DAergic) neurons in sunstantia nigra, thus, produces progressive disability.
8 Pages(2000 words)Essay
Parkinsonism and other Extrapyramidal Diseases
The cites were edited for MLA style, which was indicated in the instructions. I also edited he references to MLA format as indicated, but once again, was unsure where they belong in the paper. I cannot guarantee the document to be plagiarism free because you did not have quotation marks around areas that you took directly from other sources, however, with cites in place, this should not be an issue.
19 Pages(4750 words)Essay
Mass Media and Its Role in Society
According to the paper the commonly used term ‘mass media’ encompasses numerous institutions and individuals that differ in method and purpose. In general usage, the term has been considered to define groups who make up the communications profession in both the entertainment and news industries. The specific role of the media in society is often debated but what is not argued is that access to information is essential to the health of a democratic society.
7 Pages(1750 words)Essay
Toxic Asset (Business Law)
The price of toxic assets at which they are acquired do not reflect the real value of the assets, which results in increasing the risk factor associated with the toxic assets. Some of the major risks associated with the toxic assets include minimization of banks’ liquidity,
6 Pages(1500 words)Essay
Narcissism and toxic leadersheip
The most characteristics depicted by such leaders are mostly arrogance, hostility towards others and a sense of dominance. Though narcissism can be positive however leaders depicting such behaviors
7 Pages(1750 words)Essay
Toxic sugar
Having considered a long period of time, there is a high probability that changes in factors such as living standards that affect other factors to type two diabetes. The changes would therefore
2 Pages(500 words)Essay
Toxic Culture
From my understanding of leadership and organizational culture, leadership is responsible for setting up the organization culture, and in turn, the set culture influences the leadership (Malby, 2007). In the article Who’s to Blame for Creating a Toxic
1 Pages(250 words)Essay
Let us find you another Essay on topic MPTP and Its Role in Toxic Parkinsonism for FREE!
Contact us:
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us