We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Nobody downloaded yet

Paper review on haematological malignancy - Essay Example

Comments (0)
Summary
Marco Ladetto, Sonia Vallet, Andreas Trojan, Maria Dell'Aquila, Luigia Monitillo, Rosalba Rosato, Loredana Santo, Daniela Drandi, Alessandra Bertola, Patrizia Falco, Federica Cavallo, Irene Ricca, Federica De Marco, Barbara Mantoan, Beata Bode-Lesniewska, Gloria Pagliano, Roberto Francese, Alberto Rocci, Monica Astolfi, Mara Compagno, Sara Mariani, Laura Godio, Lydia Marino, Marina Ruggeri, Paola Omed, Antonio Palumbo, and Mario Bocc
Download full paper
GRAB THE BEST PAPER

Extract of sample
Paper review on haematological malignancy

Download file to see previous pages... One of the key enzymes of the pathways resulting in the production of prostaglandins is Cyclooxygenase-2 (COX-2) specifically in the tissue, which is being insulted, and either on the way to transform to or has been transformed to a malignant tissue. Among these cancers, some common ones are: lung, head and neck, ovarian, uterine cervix, colorectum, and breast. Even in the presence of high level of convincing data supporting the role of COX-2 in the progression of cancer, no definitive evidence is available which provides any clue to the relationship between COX-2 and haematological cancers.
Myeloma (MM) is very well described as the deregulation of the cytokine network accompanied by secretion of inflammatory cytokines. A study was carried out to look for the COX-2 deregulation in the pathogenesis of MM.
For this purpose, a sample of 142 specimen form 132 patients with plasma cell dyscrasias were taken and further tested for the expression of the proteins by Western Blot (WB) method. These patients were at different stages of the diseases as far as the advancement or severity was concerned. These specimen samples were taken after the informed consent from the patients were obtained. Clinical features of all the patients were documented. Apart from WB, real time Polymerase Chain Reaction (PCR) were also carried out for some specimen. Along with these, COX-2 immunochemistry as well as separation of plasma cells was also performed. For statistical inferences, descriptive, univariate and multivariate analyses were done by using Cox model.

Apart from the validation and assessment of MM samples and correlation between COX-2 expression and clinical parameters, the prognostic value of COX-2 expression in MM was also determined. It was found that median overall survival (OS) follow up for the study participants was 48 months and the relationship between COX-2 positive and negative was (28 months vs 52 months) and it was significantly different. While Progression Free survival (PFS) was estimated as 18 months for positive and 36 months for negative patients and it was also significantly different. COX-2 was found to be related to MM as a prognostic factor and it opened the venue for treatment options for MM as well as for more research work in the same and related areas to further explore any other associations.





Significant contribution of the study
The research work presented in this article is the first scientific report on the relationship between Cyclooxygenase-2 (COX-2) and Multiple Myeloma (MM). This is indeed an important finding, which adds to the available evidence on two facets: 1) apart from solid tumor, COX-2 has got a relationship with haematological malignancies especially with multiple myeloma where it showed statistically significant association with short progression free period in COX-2 positive patients as compared to COX-2 negative patients (18 vs 36 months; P < .001) and at the same time poor overall survival in COX-2 positive ...Download file to see next pagesRead More
Comments (0)
Click to create a comment
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
Review paper
Virus diseases inflict a heavy illness and economic damage on humans and animals and can injure agricultural crops. Each viral particle, called virion, consists of genetic material, DNA or RNA,
4 Pages(1000 words)Essay
Review paper
Having been invaded by Japan in the past made Korean sentiment towards the Japanese unfavorable. The book talks about much of this interplay between Asian nations and the country of Korea in the
3 Pages(750 words)Essay
Review Paper
Sometimes it is not possible for ethical decisions to favor each party involved. Sometimes the decision can hurt one person by favoring the lives of others. Before these decisions are made, it is important to consider which decision is going to have
2 Pages(500 words)Book Report/Review
Paper review
The introduction of the article deals a lot with the specific topic of technological innovation. The availability of technological innovation has to be utilized by employees so that management can
2 Pages(500 words)Essay
Review Paper
Advertisements for the P’Zolo illustrate a hot and crispy wrapped product of considerable length as measured by the actor’s hand and
3 Pages(750 words)Essay
Systemic paper review
This paper will research a review of articles that factors the perceived influence to the performance and motivation of nurses. The improvement of nurses’ performance will be done by looking at the relationships between
4 Pages(1000 words)Essay
Malignancy (Cellular Pathology)
18). The normal squamous cells are also consistent in their size and shape, unlike the cancerous squamous cells which appear to have very different shapes and sizes. Using the image only, those are the clear observations
3 Pages(750 words)Case Study
Review paper
Apart from this, racial discrimination continues to be exposed in socioeconomic disparity and has taken a modern form affecting contemporary society in terms of employment, housing and education. This essay presents a review of
5 Pages(1250 words)Essay
Business paper review
tly pinpoint the problem that he is trying to solve for the junior sailors, although the first paragraph gives a hint that the problem may have to do with training of junior navy sailors. In addition, the brief summary of the problem does not specifically identify how the
2 Pages(500 words)Essay
Review paper
According to statistics one million children below the age of five years pass away because of infectious diseases and malnutrition. Most of these children can be saved by providing them with adequate healthcare thus, this problem comes under
2 Pages(500 words)Essay
Let us find you another Essay on topic Paper review on haematological malignancy for FREE!
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us