We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Nobody downloaded yet

Fatigue and Limbic Dysfunction in Parkinsons Disease - Essay Example

Comments (0)
Summary
I have additionally edited this document for reference cites that were not originally provided. The cites needed to be double checked as well because the volume numbers of journal entries were missing. The cites that I found referenced in the paper, I added to the reference page, however, many of the cites you provided, I did not find referenced to in the paper, so those were omitted…
Download full paper
GRAB THE BEST PAPER

Extract of sample
Fatigue and Limbic Dysfunction in Parkinsons Disease

Download file to see previous pages... In essence, I did the best I could with what I was provided.
Parkinson's disease (PD), first described by James Parkinson in 1817 (Figure 1), is one of the most prevalent disabling illnesses that can occur later in life. It is estimated to affect 1% of 70-year-olds, but is also seen in younger people, with 10% of cases occurring before the age of 50.
The disease has become the pathfinder for other neurodegenerative disorders, since discovery of dopamine deficiency within the basal ganglia led to the development of the first effective treatment for a progressive neurodegenerative condition. Dopamine replacement therapy substantially reduces the symptoms of Parkinson's disease in most patients, improving their quality of life and initially appearing to decrease mortality.
Patients with PD who experience such central fatigue have pathology causing reductions in dopamine and serotonin turnover within the basal ganglia and limbic circuits. These are the structures, which facilitate the link between emotion/motivation (limbic system) and motor response.
Estimates of the annual incidence of Parkinson's disease are in the range of 4-20 per 100,000 individuals. ...
Demonstrating an association between fatigue and limbic dysfunction in PD will help rationalise treatment approaches for this disabling illness and its symptoms.
Incidence and Prevalence
Estimates of the annual incidence of Parkinson's disease are in the range of 4-20 per 100,000 individuals. A widely accepted figure for the prevalence of Parkinson's disease is approximately 200 per 100,000 populations. In the Unite States, it is estimated that between 750,000 and 1.5 million people have the disease. In the United Kingdom, there are approximately 120,000-130,000 diagnosed cases, but there may be many more that remain undiagnosed.
Age, Sex, and Ethnicity
Both the incidence and prevalence of Parkinson's disease increase with age, and the prevalence may be as high as 1 in 50 for patients over the age of 80 years. Men are 1.5 times more likely than women to develop the condition are. Hospital-based studies have suggested that Parkinson's disease is less common in the Black population, than in other groups.
Pathology
The main pathological feature of Parkinson's disease is the degeneration of neuromelanin-containing neurons in the pars compacta of the substantia nigra (Figure 1.1). Examination with the naked eye reveals pallor of this area, which is confirmed microscopically by a marked decrease in the number of neuromelanin-containing cells and the presence of Lewy bodies in the remaining nigral neurons. Degeneration of pigmented neurons in the brainstem is not limited to the nigra but extends to the locus ceruleus and the dorsal motor nucleus of the vagus. Lewy bodies are intracytoplasmic eosinophilic inclusions, which are typically found in the neurons of the substantia nigra (Figure 1.2). They are a pathological hallmark of ...Download file to see next pagesRead More
Comments (0)
Click to create a comment
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
Fatigue
Fatigue failure occurs through the propagation of microcracks due to repeated cyclical stresses. This type of failure is not characterised by the same visible signs as static failure; there is neither buckling nor deflection, and the internal cracks that lead to fatigue failure are not always visible to the naked eye.
9 Pages(2250 words)Essay
Parkinsons Disease
As a person ages, various forms of physical challenges begin to set in and in most cases this tends to make them begin undergoing a mental degradation. Parkinson’s disease comes second among the most common neurodegenerative disorders with the greatest effect in movement.
4 Pages(1000 words)Research Paper
Analysis of the Causes and Treatment of Parkinsons Disease in a Patient
There is a detailed discussion of the pharmacological and non pharmacological measures taken to manage PD, and the long term care that should be given to patients suffering from the disease. The last section is a conclusion based on the matters discussed in the essay and basically summarizes the facts of the research and projects the future prospects of the disease.
11 Pages(2750 words)Essay
Parkinsons Disease
Parkinsons disease (PD) is a common progressive neurodegenerative disorder that is characterized by the loss of striatal dopamine (DA) as a result of degeneration of dopaminergic (DAergic) neurons in sunstantia nigra, thus, produces progressive disability.
8 Pages(2000 words)Essay
Exposure to acute and chronic stress has been linked closely with the development of addiction and vulnerability to addiction relapse. Your task is to describe
This link will then be applied to the theories formulated with respect to behavioural addictions such as ‘Gambling’ and similarities and
20 Pages(5000 words)Essay
Parkinsons disease
Ellis, 210) which causes a huge burden on the sufferer himself, his carers, family and the over all medical systems (Rubenstein, 305) Its occurrence is seen in less than 50 years of age one out of seven patients, and the occurrence increases with the increase in age. At
4 Pages(1000 words)Essay
Limbic encephalitis
rain which includes (i) hippocampus, (ii) thalamus, (iii) hypothalamus and (iv) amygdala which are involved in vital memory and much of the behaviour related to hormones, sex, fight or fight responses, food, the perception of competition and pleasure with others, etc. Rational
12 Pages(3000 words)Essay
Parkinsons Disease
Despite many studies conducted about the disease, the cause of it is unknown. It is known that the mutation of genes in the family will likely to pass it on to the next generation. Factors like toxins, smoking, and vitamin E deficiency is shown to play a role in its prevalence to as the brain and the nervous systems are sensitive to their presence.
7 Pages(1750 words)Essay
Review the current and potential future treatments for Parkinsons Disease
It shall illustrate Parkinson Disease, its symptoms, pathology, genetics, aetiology, and explores current and future treatments of the disease. Parkinson ’s disease is a chronic neurodegenerative disorder of the central
14 Pages(3500 words)Essay
Treatments for Parkinsons disease are not able to either arrest nor completely cure the onset of the condition. Explain what problems prevent successful treatment of people suffering from Parkinsons disease
sulting symptoms of the disease are thought to be as a result of progressive nerve cell degeneration, especially for neurons located in the brain’s center (Shenkman, 2013: p12). Consequently, the brain is unable to release dopamine, which acts as a messenger to ensure smooth
2 Pages(500 words)Essay
Let us find you another Essay on topic Fatigue and Limbic Dysfunction in Parkinsons Disease for FREE!
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us