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NSAIDs also reduce clotting action specifically aspirin, an NSAID. These are commonly used to treat mild to moderate pain such as headaches and menstrual cramps and it is also given to patients with fever and minor inflammation. Not just that, it is also a mild pain reliever, and with this they not only attack pain but the source of pain as well as it is said to be anti inflammatory. As these are the main benefits of NSAIDS, they also offer other health benefits. The use of NSAIDs in minimal doses may also help prevent heart attack and stroke. With the Aspirin having that effect on clotting, they may be helpful in those patients with heart ailments such as ischemia.
When we say that NSAIDs are anti inflammatory, they act on the inflammation process in the body. When there is a trauma to the body, say for example a cut, prostaglandins are produced by the cells and they will be directed to the site of the trauma. They promote inflammation, pain, and fever if there is infection. These prostaglandins are produced within the body cells by the enzyme cyclooxygenase (Cox). There are two Cox enzymes, Cox-1 and Cox-2, both enzymes produce prostaglandins that promote inflammation, pain and fever. NSAIDs block the Cox enzymes and reduce prostaglandins in the body. As an effect ongoing inflammation, pain, and fever are reduced.
As NSAIDs have an effect on the inflammation process it also has effects on pain management but only limited from mild to moderate pain. So how is this so? Inflammation on the first place occurs when there is acute soft tissue injury which then causes these damage cells to release chemicals that causes vasodilation and extravasation which are responsible for inflammation and pain. And since NSAIDs act on these actions, they would help in reducing pain by first reducing what caused that pain. For example, pain is caused by the inflammation, NSAIDs would act first on the inflammation process before it would reduces pain. However the study cited warns that NSAIDs should only be used on the early stages of inflammation and should be stopped as soon as possible since NSAIDs may only act on the early stages of inflammation (Dunitz, M. 2001).
What now could be the effect of NSAIDs in fever In one research, in the pathogenesis of systemic inflammation and fever, signals can be transmitted through humoral and neural routes. Neural routes can be through chemo sensitive afferent fibers of the abdominal vagus and that the study concluded that capsaicin-sensitive fibers traveling within the hepatic vagal branch constitute a necessary component of the afferent mechanism of the febrile response to low, but not high, doses of circulating pyrogens. We speculate that this mechanism is triggered by blood-borne prostaglandins of the E series (Romanovsky, A. et.al, 2000). And as it is worked about by prostaglandins, and since prostaglandins are the main target of NSAIDs, it then helps the body to recuperate from fever.
But as the effect of prostaglandin in the body is affected by NSAIDs, they also have effects which are not beneficial to the body. These effects are then what we call the side effects. The most common side effects of NSAIDs are the following, nausea, vomiting, diarrhea, constipation, decreased appetite,
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“Hypertension is usually defined as a systolic pressure above 140 mm Hg and a diastolic pressure above 90 mm Hg.”. The risk of hypertension increases with the advancement of age. The principle cause of stroke is hypertension because increased blood pressure causes hypertrophy and other changes in the vasculature of the left ventricle. Furthermore, hypertension increases the risk of coronary artery disease and renal failure.
It affects adults as well as children and is a global health problem (Australian Centre for Asthma Monitoring 2011). It frequently has associations with COPD, allergies, rhinitis and other respiratory diseases. So far as definition is concerned, there is no gold standard definition.
The systematic reviews done prove and shows that NSAID is effective in pain or even help cure cancer patients. The results of the systematic review of the journals are being presented in the table. The authors who make the study was able to show the methods they used in analyzing the NSAID. Non steroidal anti-inflammatory drugs are medications which, as well as having pain-relieving (analgesic) effects, have the effect of reducing inflammation when used over a period of time.
Introduction [...] Non – Steroidal Anti-Inflammatory Drugs (NSAIDs) [...] is the most widely used pain [...] reliever nowadays NSAID are drugs used [...] to reduce pain fever and inflammation [...] It is called non steroidal to [...] distinguish it from steroids which have [...] a similar eicosanoid-depressing anti-inflammatory action NSAIDS [...] are unusual in that they are [...] non-narcotic NSAIDs are sometimes also referred [...] to as non-steroidal anti-inflammatory agents/analgesics (NSAIAs) [...]
The author was determining the analgesic and anti-inflammatory properties of lavender angustifolia by testing the hydroalcoholic extract, polyphenolic fraction and essential oil of the leaves. The standard method, which has been adopted by the author, was the gas chromatography with mass spectrometry (GC/MS).
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Despite a sizable resistance due to its demonstrable benefits as against the conventional practice, such as, improvement in patient care,
S phase characterizes the DNA synthesis, G2 phase is the post-DNA synthesis phase and the M phase is the final cellular activity in which the cell undergoes mitosis resulting in production of two daughter cells. The tumor or cancer cells also
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