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Allogeneic Blood Transfusions - Assignment Example

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The author states that there is a concern in the use of allogeneic blood transfusion, because of the risk factors associated with exposure to allogeneic blood transfusions. These risks include the potential for infectious diseases, immunomodulation and transfusion reactions…
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Allogeneic Blood Transfusions
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Download file to see previous pages The first factor is the failure to identify the transmissible infectious pathogens that are present in the donor population and for which there is the need for screening of the donor blood. The second factor is the failure to detect donor blood containing these infectious agents, even when screening of the donor blood is done (Kitchen & Barbara, 2008).
The first factor is based on the fundamental need in allogeneic blood transfusion to make sure that the appropriate infectious pathogens are screened for in the donor blood. Universal screening uses the thumb rule that all donations be screened for the viral agent's hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) and the bacterial agent responsible for syphilis (Treponema pallidum). This raises the issue of the remaining infectious agents like those responsible for Chagas disease and human T-cell lymphotropic virus. Many such infectious agents are not geographically widespread and are restricted to certain continents, regions or countries in the world. Thus their presence is not universal restricting the need for universal screening of these infectious agents. The additional screening policy for infectious should be based on the relevant prevalence of these infectious agents narrowed down to the donor population in the country or region (Kitchen & Barbara, 2008).
The second factor is an even more critical issue in infectious risks of allogeneic blood transfusion. The failure to detect an infectious blood donation in the screening program may arise from several reasons of human error to biological variability. While failure to detect infectious blood donation due to scientific or biological variability is difficult to remove, failure to detect infectious blood donation from human error is manageable through well-developed and managed blood transfusions. ...Download file to see next pagesRead More
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