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Project The Wellcome Trust - Research Paper Example

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This research paper called Project "The Wellcome Trust" describes the B29R gene in the Vaccinia virus. From this work, it is obvious that the strategy proposed is to determine the gene sequence and perform in situ analysis to infer function…
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Project The Wellcome Trust
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Download file to see previous pages 1. Take all reasonable actions to ensure that the Trust’s contribution to the funding of the research is suitably acknowledged.
2. Ensure that all research papers (whether based wholly or partly upon the research to be funded by the grant) are forwarded to the Trust upon publication.
3. Comply as Trust-funded researchers with the Trust’s principles and policies on relationships between Trust-funded researchers and commercial entities as set out in Annex A to the Trust’s grant conditions.
4. Consult with Wellcome Technology Transfer, prior to entering into an arrangement with any enterprise that will provide for the exploitation of any results arising from any activity funded under a Trust award.
5. Promptly inform the Trust of any material changes during the period of the Grant to any of the details provided in this application.
In signing the application form where shown below, and in consideration of the receipt of this application by the Trust, the Head of Department UNDERTAKES that the information provided in the application form and otherwise in connection with this application is to the best of his/her knowledge and belief accurate and complete and that, in relation to any Award of Grant resulting from the application, he/she will:
1. Ensure compliance with the Trust’s principles and policies on relationships between Trust-funded researchers and commercial entities as set out in Annex A to the Trust’s grant conditions.
2. Consult with Wellcome Technology Transfer, prior to entering into an arrangement with any enterprise that will provide for the exploitation of any results arising from any activity funded under a Trust award.
3. Promptly inform the Trust of any material changes during the period of the Grant to any of the details provided in this application.
The proposed project aims to isolate, clone, and identify the specific ligands for B29R, a Vaccinia virus protein found at the C-terminal region of the genome. Initial analysis of this protein has identified it to be a 24 kDa protein with motifs similar to chemokine binding proteins that are implicated in virus entry and compromising the host response. The strategy proposed is to determine the gene sequence and perform in situ analysis to infer function.
Using an expression vector, the protein will be expressed and its specific ligand will be identified by screening different human chemokines using surface plasmon resonance. Based on the chemokine that will be identified to be specific for B29R, knockout mice without the gene for the ligand will be given doses of the virus to induce infection and symptoms. This will validate the binding specificity of the protein and chemokine. ...Download file to see next pagesRead More
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