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Overview of Disease: Asthma - Assignment Example

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The author of the paper examines asthma which has been defined to be a disease of the airways resulting from chronic inflammations of various aetiologies. In this disease, the tracheobronchial airways become extremely responsive to a variety of stimuli. …
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Overview of Disease: Asthma
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Download file to see previous pages According to statistics, the current number of patients in the United Kingdom is 5.1 million. This number has increased from the previous study. About 8% of adults and 13% of children are affected, and this increased trend has been postulated to be due to a combination of genetic, environmental, and population growth factors. There is a number of emergency hospital admission and death due to this disease (SIGN and BTS 2009).
Asthma is heterogeneous in terms of etiology. Atopy is a common cause, and genetic factors are involved in the transmission of these atopic traits. Some environmental factors which the individual may be exposed in the domestic or occupational environments may also trigger asthma. These are viruses, allergens, dust mites, and others. These also contribute to asthma trigger and continuance of the disease. The most important risk factor is allergic diathesis or atopy. In many cases, no such links have been described, (Satta, 2000).
Asthma leads to subacute inflammation of the airways. The persistent nature of this inflammation leads to edema of mucous membranes. With inflammation, the inflammatory cells infiltrate the mucosa. This also leads to increased congestion in the blood vessels due to the slowing of circulation. With the external triggering agent, the inflammatory cells accumulated in the mucosal epithelium which release inflammatory mediators leading to amplification of the basic inflammatory process, which culminates into an intense and immediate inflammatory reaction leading to constriction of airways, vascular congestion, edema, increased mucus production, and inability expectorate due to impaired mucociliary transport. These events are followed by a chronic inflammatory stage giving the disease a characteristic acute, chronic, and acute-on-chronic picture (Nici et al, 2006).  ...Download file to see next pagesRead More
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