Cellular and Molecular Biology of Human Melanoma - Essay Example

Biologically, tumor development is triggered by some elements in the skin. Inflammatory cells, dermal fibroblasts, epidermal keratinocytes, and endothelial are some of the components that trigger tumor development. The keratinocytes keep melanocytes in check from continuous and multiplication this fine balancing contributes to healthy skin. Melanocytes are prevented from migrating into the dermis by a well-defined basement membrane, (p. 16). Because of the foreign environment nature, isolated melanocytes cannot survive in the dermis.

Melanocytes are inhibited from hostile cell multiplication due to a lack of complete modification in a dermal nevus. Therefore melanocytes stay in a collection and may even terminate the basement membrane barrier.Finally, it can be said that melanoma evolves as a result of complex perturbations. The high adaptability of melanoma to varying microenvironments proves its ability to attack and metastasize distant body organs in the body, (p. 17). There is a need for robust and particular therapeutic intermediation for melanoma development.

A compounded plan of action for restoring normal homeostasis in the epidermis with targeted deposition of apoptosis-inducing agents could be ideal.