Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation by Nakaoka and Komuro - Article Example

Nakaoka and Komuro (2012), in this article, were determined to provide an overview of the structure, regulation, and effector functions of the Gab docking proteins with the primary focus on their relationships with cancer, inflammation, and cardiovascular disease. These researchers identify that the docking proteins of the Grb2-associated binder family have significant signaling compartments in metazoans (Nakaoka & Komuro, 2012). They also present that the Gab proteins, in mammals, comprised of Gab1, Gab2, and Gab3 participate in the integration and amplification of signal transduction triggered by a number of extracellular stimuli such as growth factors, antigens, and cytokines, including other molecules (Nakaoka & Komuro, 2012).

These researchers performed a number of studies to establish the relationship of Gab docking proteins with cancer, inflammation, and cardiovascular disease by investigating the roles of these proteins in cardiomyocytes, vascular inflammation, atherosclerosis, angiogenesis, liver regeneration, bone homeostasis, human cancer, and human cardiovascular protein. Their study established that docking Gab proteins play key roles in a number of psychological processes, including disorders such as inflammation, cancer, and cardiovascular diseases.

These authors further assert that, although the molecular mechanism of this relationship remains unclear, further researches focusing on Gab proteins will enhance the elucidation of the pathophysiology of adult asthma, in the near future (Nakaoka & Komuro, 2012).