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Safety of Soy-Based Infant Formulas - Assignment Example

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 In the paper “Safety of Soy-Based Infant Formulas,” the author analyzes classical galactosemia, which is an autosomal recessive disorder of galactose metabolism due to the deficiency of galactose-1-phosphate uridyltransferase (GALT), which is necessary for the conversion of galactose-1-phosphate…
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Safety of Soy-Based Infant Formulas
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Download file to see previous pages If the condition is not detected at birth with proper testing, symptoms usually occur within the first few days or weeks of life after the baby drinks breast milk or a lactose-containing formula. The buildup of galactose can cause severe damage to the liver, kidneys, central nervous system, and other body systems.
A less severe form of this disease is Duarte galactosemia or galactokinase deficiency. This condition can be managed with a few dietary restrictions, and there is no risk of neurologic or liver damage. However, cataracts can develop.
Following symptoms and signs are present: poor feeding and poor weight gain, vomiting and diarrhea, jaundice, cataracts, lethargy and hypotonia, hepatomegaly, encephalopathy, bulging or full fontanelle, bleeding or excessive bruising, and improvement of the condition with intravenous fluids (Walter et al., 1999.)
1. Beutler test- this is a widely used fluorescent spot test for galactose-1-phosphate transferase activity in the diagnosis of galactosemia. However, false-negative results are possible following recent blood transfusions (within three months). False-positive results can occur with glucose-6-phosphate dehydrogenase deficiency (Walter et al., 1999.)
2. Red blood cell galactose-1-phosphate transferase assay- this is a quantitative assay to confirm the diagnosis of galactosemia. This test can identify variants of galactosemia with residual enzyme activity. As in the Beutler test, false-negative results are possible within three months of a blood transfusion. In case there is difficulty in establishing a diagnosis, the measurement of galactose-1-phosphate transferase in the red cells of both parents can be done to establish their carrier state (Walter et al., 1999.)
3. Red blood cell galactose-1-phosphate- the concentration of galactose-1-phosphate is always raised in classic galactosemia and is not affected significantly. ...Download file to see next pagesRead More
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