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The Role of Nuclear Medicine in Hyperthyroidism - Assignment Example

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This paper “The Role of Nuclear Medicine in Hyperthyroidism” reveals that radionuclide imaging is an important diagnostic modality in the workup of hyperthyroid disorders, but despite that, in some cases, the diagnostic yield is better with ultrasonography or PET scanning…
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The Role of Nuclear Medicine in Hyperthyroidism
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Download file to see previous pages The thyroid gland produces two hormones, namely, thyroxin (T4) and triiodothyronine (T3). These are known to play important physiological roles in the human body. Anatomically, the thyroid gland is located in the neck, in front of the trachea. It comprises of two lobes, right and left, connected by a narrow bridge of thyroid tissue, known as the isthmus. It is a very highly vascular organ. The normal adult thyroid gland consists of follicles lined by thyroid follicular cells that contain a large amount of thyroglobulin. This serves as the protein precursor of the thyroid hormones (Broome, 2006). Endocrinologically increased the need for thyroid hormone leads to a signal pathway mediated by thyroid stimulating hormone (TSH) leading to release of active hormone from a bound state with thyroglobulin to a free state, eventually being secreted into the bloodstream. When there is hypersecretion of thyroid hormones due to any cause, the condition is known as hyperthyroidism. Usually, hyperthyroidism is indicated by an elevated level of TSH. Flower et al. (1990) performed comparative studies of 41 hyperthyroid patients, who had clinically two types of diagnoses, namely, Graves' disease and multinodular goiter. The interventions performed in all patients were sequenced with ultrasonography, PET using 124I, followed by gamma camera pinhole imaging scintigraphy subsequent to 131I therapy. The last was not performed with a diagnostic intent, but the findings correlated well with 124I PET imaging that would determine the relative size of the lobe.  ...Download file to see next pagesRead More
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