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Toxicity with chemotherapy Pharmacogenomics and Predictors of toxicity - Essay Example

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Fanconi anemia (FA) is a genetic disease characterized by physical abnormalities, such as short stature, abnormal skin pigmentation, internal organ malformation, thumb deformation, hypogonadism, and development delay, as well as bone marrow failure and increased risk of malignancy…
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Toxicity with chemotherapy Pharmacogenomics and Predictors of toxicity
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Download file to see previous pages This research thus asks, “In AML patients who have undergone chemotherapy, what FA genes are predictive of developing secondary aplastic anemia? To answer this, the experiment will be conducted, with the general objective of suggesting genes that can be tested in order to predict the occurrence of aplastic anemia secondary to chemotherapy. Because secondary aplastic anemia is a fatal side effect of AML treatment, it is helpful to determine susceptibility to this complication before chemotherapy is ensued. One of the ways that this can be done is by looking for mutations in FA genes that predispose to the development of aplastic anemia. However, for this information to be clinically useful, testing for these genes must be quick, since AML treatment should be commenced immediately. Specific objectives include, 1) comparing FA gene mutations in post-treatment AML patients with or without secondary aplastic anemia, 2) determining predictive values of the various genetic mutations for the occurrence of secondary aplastic anemia, and 3) planning a quick screening test for AML patients before initiation of chemotherapy.


Research plan This retrospective study will employ a retrospective design to identify FA genes predictive of secondary aplastic anemia in AML patients. Sampling At least 200 adult individuals without FA that have a present or past medical history of AML and subsequent chemotherapy will be the subject of this study. They will be classified into those that had or have acquired secondary anaplastic anemia and to those that have not. Exclusion criteria will include previous bone marrow transplant and unstable health status that prevents bone marrow sampling. Methods 1. Baseline characteristics For each subjects, age, sex, and age diagnosed with AML will be tabulated. 2. Bone marrow ...Download file to see next pagesRead More
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