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Bronchial Asthma - Research Paper Example

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Asthma is a disease which becomes progressively complex over time involving the genetics and environmental stimuli as part of its pathogenesis. The hallmark of its diagnosis is the combination of bronchospasm and inflammation The writer of this paper focuses on Bronchial Asthma…
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Download file to see previous pages A series of theories were proposed to account for the pathophysiology of asthma over the past 100 years. The models of the pathogenesis of asthma have been consistent with its nature which is a complex disease per se and over time, became more progressively complex (Walter and Holtzman, 2005). A marked progress in defining the behaviours of the airways in terms of cellular and molecular mechanisms is noted. After that, research has moved forward and came up from a functional approach that is descriptive in nature to the one with cellular and molecular biology, immunology, microbiology, genetics, and pathophysiologic in nature (Walter and Holtzman, 2005). The aforementioned approached allowed current researchers to define heterogeneity of asthma in terms of quantitative and molecular approach and were able to determine its exact function on the inflammatory process of the airways that accounted likely for the initiation and progression of the disease (Walter and Holtzman, 2005). ...
cauterization of distinct pathways that are mechanistic for driving the phenotype of asthma will be aided with the advances in the research of genetics, genomics, proteomics, and lipidomics, which would later on provide biomarkers that are good enough and effective in the prevention and treatment regimens for individuals suffering from asthma (Walter and Holtzman, 2005). B. Epidemiology of Asthma 1. Worldwide Around 5 – 10 percent or an estimated 23.4 million of the population is affected by asthma. Among individuals who have no allergies or asthma, the overall prevalence rate of bronchospasm that is reportedly induced by exercise is 3-10 percent to the general population (Morris, 2012). An estimated 300 million individuals worldwide are assessed to have been affected by asthma. According to the records of the World Health Organisation (WHO), there are approximately about 15 million “disability-adjusted life – years are lost,” and 250,000 deaths due to asthma are reported around the world. 2. In Australia According to the Australian Institute of Health and Welfare (2008), the epidemiology of asthma in Australia remains unclear and reliable statistics still needs to be developed to describe this particular problem. The Australian Institute of Health and Welfare (2008) note that the Centre for Epidemiology and Research reported that in 2007, sometime in their lives, an estimated 3, 979, 476 or an equivalent to 20.3 percent Australians were diagnosed by doctors or nurses with asthma based on the data gathered in the surveys. In New South Wales, a significant increase from 16.6 percent to 19.3 percent of new cases was reported in 2006, with higher percentage noted among males than females (Australian Institute of Health and Welfare, 2007). ...Download file to see next pagesRead More
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