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Biology - Essay Example

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10% (Abstract) – Is the abstract a true representation of the experimental findings of the paper and are there constraints or limitations of the stated conclusions? The abstract of the paper on ‘Int7G24A Variant of Transforming Growth Factor-B Receptor Type is Associated with Invasive Breast Cancer’ summarizes the objective of the study, the methodology followed, the observations of the study and the conclusions made…
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Download file to see previous pages These results have been expressed quite clearly in the abstract. It gives a clear idea to the reader on the key area of research. Most of the keywords referring to the areas of research dealt in the paper have been included in the abstract. This contributes to the process of literature review. Moreover, this will also ensure that electronic scanning of the document fetches desired results. This becomes more important as this research paper does not have a separate section on keywords. The objective of the study and the background research on the subject also has been referred in the abstract. The finding that an intronic variant (Int7G24A) ofTGF-h receptor type I (TGFBR1) is involved with bladder and kidney cancer has been used in the present study. As this is mentioned in the abstract, the background of the research becomes scientifically supported. It includes within its contents, the hypothesis of the study. In totality, the abstract of the given paper serves as a real representation of the research study. A limitation with the precision of the results is that the sample size is too less. However, the conclusions made by the paper are an ideal reference material for further research in the area. 10% (Introduction and Hypothesis)- Can you identify the experimental hypothesis (or determine if there is one) and critically analyze its “testability”? The experimental hypothesis of the study is that intronic variant (Int7G24A) of TGF-h receptor type I (TGFBR1) is involved in development and progression of breast cancer. The fact that the hypothesis has been clearly indicated in the abstract itself makes it identifiable. The testability of the hypothesis is supported by the background research done in the same area. The author has done extensive literature review to form the foundation of this research. Thus the initial conception of the thesis has been done on the basis of these scientific evidences. The findings of earlier studies on the current subject of research (germline variant is an important genetic marker as far as metastatic breast cancers are concerned) has been used by the researcher to conceptualize the hypothesis. Another key point which would determine the scientific effectiveness of a hypothesis is the capacity to bring out analyzable results. As the study analyzed specimen tissue from all the members of the sample population using tested and calibrated scientific measurements, it could quantify observations into analyzable forms. Samples were also taken from 153 non cancer female controls serving as the reference information to analyze the data. Having included these provisions, the hypothesis can be concluded as testable. Having followed these basic testability principles, the experimental hypothesis used in the study is scientifically valid. 20% (Materials and Methods) – Is there sufficient detail in the materials and methods section for you to repeat the experiments and do the proposed experiments address the hypothesis? What information is missing? A detailed record of the subjects has been explained in the paper. The sample history has been mentioned in the chapter. It has been stated that paraffin-embedded surgical specimens of patients were retrieved from the archives of the tissue bank at Wood Hudson Cancer Research Laboratory. These samples ranged from 10 to 20 years old. This information is ...Download file to see next pagesRead More
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