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Cushing's Syndrome - Research Paper Example

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Cushing’s syndrome Name Subject Teacher Date               Abstract Cushing’s syndrome is an uncommon disease caused by hypercortisolism that arises from the overactivity of the adrenal glands, the overproduction of ACTH by the pituitary gland, the excess in the CRH secretion of the hypothalamus, and other factors…
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Cushings Syndrome
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Download file to see previous pages Moreover, the key to the management of the disease in both humans and animals involves proper medication, development of a healthy lifestyle and a strict diet, although further research on these is necessary. Cushing’s syndrome Definition Cushing’s Syndrome is a hormonal disorder caused by an abnormal increase in the amount of the hormone cortisol in the blood, but since it may not only be cortisol that is in excess but also other related hormones, then Cushing’s Syndrome is conveniently defined as “prolonged and inappropriate high exposure of tissue to glucocorticoids” (Nieman et al., 2008). Glucocorticoids are steroid hormones that turns down the inflammation system as a sort of negative feedback mechanism, and so they are used in diseases where the immune system of the patient is overactive. If, therefore, there is an overproduction of glucocorticoids, especially cortisol, in the blood, then the result is the overall turning down of the entire immune system, thus leading to numerous physiological disturbances that define Cushing’s syndrome (Nieman et al., 2008). ...
lso cases where Cushing’s syndrome is termed as familial in that the formation of tumors in the body is inherited and passed on to the next generation. The biochemical mechanism behind Cushing’s syndrome is rather simple: the overproduction of ACTH by the pituitary gland triggers the release of too much cortisol by the adrenal glands. Moreover, an excess of corticotrophin-releasing hormone, or CRH, from the hypothalamus may also trigger the pituitary gland to release too much ACTH (Nieman et al., 2008). Nevertheless, the most common mechanism behind Cushing’s syndrome is the stimulation of the adrenal glands by ACTH in order for these to produce cortisol. ACTH does this by enlarging the adrenals and causing the protein synthesis in it to increase, and the most common danger is that when these ACTH levels are decreased through treatment and the rate of protein synthesis slows down, then the adrenal glands might atrophy (Blevins, 2002). Thus, the importance of detecting Cushing’s syndrome early cannot be emphasized too heavily. Symptoms that make up Cushing’s syndrome include “reddish purple striae, plethora, proximal muscle weakness, bruising with no obvious trauma, as well as unexplained osteoporosis” (Nieman et al., 2008). Other symptoms include “obesity, depression, diabetes, hypertension, or menstrual irregularity” (Nieman et al., 2008). Moreover, since hypercortisolism – which is the hallmark of Cushing’s syndrome – involves both physiological and psychopathological consequences, the disease may be characterized by certain psychiatric disorders such as anxiety disorder, depression, obsessive-compulsive disorder, alcoholism and diabetes mellitus. These symptoms are caused by corticotrophin-releasing hormone, or CRH, which is released by the ...Download file to see next pages Read More
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