StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...

Coagulation: Overview, Pathways, Clot Formation, and Effects on Coagulants - Essay Example

Comments (0) Cite this document
Summary
Coagulation: Overview, Pathways, Clot Formation, and Effects on Coagulants Coagulation: Overview The process of blood clotting is referred to as coagulation, which is essential during hemostasis. Hemostasis takes place in order to terminate the flow of blood from an injured vessel (Hoffbrand, Moss & Pettit 2006)…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER93.1% of users find it useful
Coagulation: Overview, Pathways, Clot Formation, and Effects on Coagulants
Read TextPreview

Extract of sample "Coagulation: Overview, Pathways, Clot Formation, and Effects on Coagulants"

Download file to see previous pages The process of coagulation requires a platelet and a coagulation factor in order to function, which usually involves a cell and a protein. It automatically starts once the endothelium lining of a blood vessel has been affected due to damage (Hoffbrand, et. al 2006). When the blood is exposed to protein components, the site's blood platelets and plasma fibrinogens would react towards the damage and begin the clotting process (Mann, Brummel-Ziedins, Orfeo & Butenas, 2006). Primary hemostasis commences, wherein platelets would form a plug where the vessel has been damaged. After which, the secondary hemostasis proceeds concurrently, wherein coagulation factors located in the blood plasma would react towards the cascade to produce fibrin strands, in order to reinforce the platelet plug (Hoffman & Monroe 2007). The Coagulation Cascade The coagulation pathway is also referred to as the blood clotting system, which functions as a proteolytic cascade. The enzymes present in the blood clotting system are represented in the plasma in its inactive form, or as zymogens. These zymogens would then go through the process of activation by means of the proteolytic cleavage, which would trigger the active factor from the antecedent particle (Hoffman, et al. 2008). The mechanism in which the coagulation system functions is through a cycle of positive and negative feedback series that regulate the activation process. In essence, the objective of the coagulation pathway's process is to create thrombin. Thrombin would then produce the substance responsible for forming a clot, which is fibrin, which is a result of converting fibrinogen (Hoffbrand, et. al 2006). The process of creating thrombin is distributed into three stages: the extrinsic and instrinsic pathways serve as substitute conduits in producing factor X, whereas the final common pathway forms thrombin (Mosnier 2004). The formation of fibrin is achieved through two pathways of the coagulation cascade of secondary hemostasis. These two pathways are referred to as the: 1) contact activation pathway; and the 2) tissue factor pathway (Hoffbrand, et. al 2006). The two aforementioned pathways are also known as the intrinsic and extrinsic pathway. It is important to note that both pathways are equal in nature and would lead to one pathway (Hoffman & Monroe, 2001). The extrinsic or the tissue factor pathway is the main conduit in the instigation of the blood coagulation process. Both pathways serve as a string of reactions, wherein active components would be formed through the inactive enzyme precursor of a serine protease and its corresponding glycoprotein co-factor. These active components would then trigger the preceding reaction in cascade. These processes would then produce cross-linked fibrin (Mann, et. al 2006). Coagulation factors disseminate to the damaged blood vessels as inactive zymogens, and are usually composed of enzymes or serine proteases, which serve the purpose of slicing other proteins based on a definite serine deposit. Concessions to coagulation factors apart from serine proteases are glycoproteins (FVIII and FV) and transglutaminase (FXIII) (Hoffman & Monroe, 2001). The coagulation cascade is typically follows the division of three conduits. The aforementioned extrinsic and intrinsic pathways activate the common conduit of factor X, which is thrombin and fibrin (Hoffman, et al. 2008). Tissue factor pathw ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Coagulation: Overview, Pathways, Clot Formation, and Effects on Essay”, n.d.)
Retrieved from https://studentshare.org/health-sciences-medicine/1400042-coagulation
(Coagulation: Overview, Pathways, Clot Formation, and Effects on Essay)
https://studentshare.org/health-sciences-medicine/1400042-coagulation.
“Coagulation: Overview, Pathways, Clot Formation, and Effects on Essay”, n.d. https://studentshare.org/health-sciences-medicine/1400042-coagulation.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Coagulation: Overview, Pathways, Clot Formation, and Effects on Coagulants

Effects of El Nino in Asia

The warm current off the coast of South America appears after Christmas which led the Spanish sailors in Peru to call it El Nino. El Nino means little child in Spanish (WHO, 2000).
El Nino is caused when the winds that push the water get weaker. Due to the weaker winds, the warm water that has been accumulated in the west comes back towards the east. At the same time, sufficient cold water is not pulled up from the bottom. These two factors contribute to the warming up of the water and the growth of El Nino. The winds get weaker and the ocean gets warmer and the warmer ocean further makes the winds weaker. The process continues and the El Nino continues to grow (Scripps Institution of Oceanography, 1997). The warming continue...
11 Pages(2750 words)Assignment

Nursing Shortage: How it Effects Nurse Management & Leaders

Nearly twenty percent of the hospitals in 2001 had registered nurse vacancy rates in excess of twenty percent. The survey conducted on behalf of the American Hospital Association in 2001 showed that 126,000 full-time registered nurse positions were not filled. The following year in 2002 the U.S. Department of Health and Human Services that the number of states in the United States of America experiencing registered nurse shortages had gone up to thirty. The consequences of the shortage of nurses on the nursing professionals as evaluated by studies showing that the nursing professionals were experiencing burnouts, stress, and lack of job satisfaction, which was likely to compound the issue of shortage of nursing professionals. The...
10 Pages(2500 words)Case Study

Effects of Human Resource Systems on Manufacturing Performance and Turnover

Most of these developments, not surprisingly, have come from communities of scholars focusing on their own particular countries or regions, be it the US (for example, Arthur, 1994; Delery and Doty, 1996; Huselid et al., 1997), the UK (for example, Brewster, 1999; Guest et al., 2003), elsewhere in Europe (for example, D’Arcimoles, 1997; Lahteenmaki et al., 1998; Roderiguez and Ventura, 2003). The difference in perspective on the value of people in organizations and the validity of HRM, particularly in non-Western Countries may be best understood in terms of the concept of locus of human value (Jackson et al., 2003). Jackson et al. (2003) came up with a conceptual map of international organization and human resource management...
12 Pages(3000 words)Essay

Effects of Menopause on Women's Life

It is typically accompanied by some distressing physical and psychological symptoms in women that also impact middle adulthood. There is variation in the age at which menopause occurs; in the USA the average age at menopause is 51 years, but the usual range is 45 to 56 years. For unknown reasons ovaries gradually begin to change on hormone production during a womens mid-30s. In the womens the late 40s, the process speeds up and hormones fluctuate or change more causing irregular periods.

Some womens periods stop suddenly; others experience a perimenopause, a phase of irregular menstruation, and symptoms such as memory disturbance, bloating and feeling tired, that may be troublesome for 5 to 10 years. (Brown, 2002)
...
6 Pages(1500 words)Case Study

What Are the Effects of Industrial Pollution to Nature in Turkey

It is observed that electroplating and chemical industries are responsible for the generation of a considerable portion of emissions that contain heavy metals, and may affect adversely on human lives and environment. On the other hand, sugar, pharmaceuticals, and textile industries are responsible for the generation of organic pollutants in the atmosphere. Refineries, fertilizers, stone mines, and thermal power units are mainly the causing sectors of contributing a substantial amount of air pollution in the Turkish atmosphere. In specific, sulfur, nitrogen, and hydrogen sulfide are some of the main pollutants that are generated from the burning of fuels in the abovementioned industries in Turkey. Though vehicular sources also cont...
7 Pages(1750 words)Case Study

How Does the US Media Effects Evolve in Singapores Current Media

Lewis and Slade (2000, p. 223) in their critical evaluation of the effects of media communication on the audience argue that media effect is achieved incongruent with social context. Their study recounts the experiment on the influence of television on identity in Singapore indicates that US social values and Singaporean values greatly differ from each other. The sharp differences in program content have a negative influence on the audience because Chinese raised Singaporeans value marriage, social values, and collectivism whereas US social culture involves career, family and the struggle to balance the two. Therefore the question of US media's influence to destabilize Singaporean national identity is limited. This view is emphasi...
6 Pages(1500 words)Assignment

The Effects of Financial Crisis on Supplier Selection Criteria of the Oil and Gas Industry Equipment Market

It is a difficult task to find those vendors who not only have the adequate quality and quantity of the needed raw materials but who also have an attitude of efficiency and display commitment to customer service (Sonmat, 2006). Further, organizations also strive to locate and select vendors who can be depended upon for long term relationship.

The number of factors or attributes desired from the vendor is vast, and different organizations and different industries place different importance on the attributes (Sonmat, 2006). Some of the vendor attributes may gain importance owing to the nature of the industry, for example, in the case of consumer perishables suppliers, like fresh vegetables or fruits, the buying firm would...
20 Pages(5000 words)Literature review

Effects of the United States of America Troops in South Korea

Despite the few negative incidences of crime committed by the United States of America’s security troops that were deployed in the country on a peacekeeping mission.
Since the war in Korea began in the early nineteen fifties, the United States has stationed tens of thousands of soldiers, mostly the United States’ army personnel, in South Korea. Through the assistance of the South Korean troops and other neighboring governments, the American troops have been able to guard and offer maximum security to South Korean people. In line with the argument of James (2003), ‘most of the military bases in South Korea are relatively isolated’ thus the need for much attention from the troops so as to ensure maximum...
10 Pages(2500 words)Assignment

Word Formation Processes in English

While I have been learning French for years, yet, only basic concepts like the meanings, pronunciations, and basic grammar rules are concerned, I want to understand more about the linguistic aspect, especially the morphological one, of the language. This includes the formation processes of French words and how the French internet languages are different from the traditional word-formation processes. I as well want to discover new information on the computer-mediated languages to improve my informal understanding of both English and French. I am also eager to learn more about the morphological word formation so that I can become a better language teacher.
Linguists categorize words as the small units of syntax within a given l...
12 Pages(3000 words)Assignment

Living Longer and Its Effects

In the 20th century, life expectancy did rise radically amongst the wealthiest populations of the world from about 50 years to above 75 years (RGS organization, 2014). In accordance with the National Centre of Health Statistics, men’s’ life expectancy back in the year 1907 was forty-five years; by 1957 the life expectancy rose to sixty-six point four; it reached seventy-five point five in the year 2007 (weblog, 2007). In accordance with researchers at Harvard University, researchers from the World Health Organization in the previous did claim that individuals live longer and healthier lives this day compared to the past. Life expectancy globally did increase from about sixty-four years in the year 1990 to around sevent...
6 Pages(1500 words)Assignment
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic Coagulation: Overview, Pathways, Clot Formation, and Effects on Coagulants for FREE!

Contact Us