Possible effects of ginseng on blood glucose in diabetic patients - Essay Example

The plant is cultivated for its man shaped roots which form an important diet supplement in Asian countries and United States. Historical records reveal the use of ginseng root for effectively treating diseases with symptoms similar to diabetes. However, researches to investigate the antidiabetic effect of Ginseng root began only in the first half of 20th century. Studies conducted by Japanese scientists on the root of Ginseng in the 1920s led to reports confirming the traditional claims of Ginseng root being effective in reducing baseline blood glucose and alleviating hyperglycemia caused as a consequence of high intake of glucose.

Ever since numerous in vitro studies, animal trials, clinical trials on the root and root extracts have supported the efficiency of ginseng in controlling blood sugar levels in diabetics and hence has been used for the treatment of diabetes (Xie et al., 2005). The constituents are ginseng root are 80%-90% organic and up to 10% inorganic with multiple active ingredients namely saponins or ginsenosides, many carbohydrates, nitrogenous substances, phytosterols, essential oils, vitamins, minerals, amino acids, peptides and organic acids.

The active ingredients reported in the extracts effective in reducing blood glucose levls have been detected with ginsenosides and polysaccharides. Ginsenosides has been identified as the principal active ingredient of the plant and its concentration is highest in the leaf, followed by berry and then roots. Besides, the profile of ginsenosides with six main ginsenosides isolated from root berry and leaf is also different. Thus it has been speculated that the relative proportions of the some of these ginsenosides determines the hypoglycemic efficiency of ginseng extracts (Xie et al., 2005). Thus hypoglycemic effect of ginseng extracts has been well documented and supported by experimental evidences.

The aim of this paper is to demonstrate the effect of ginseng on blood sugar levels in diabetic patients. METHOD PARTICIPANTS 5 subjects with type 2 diabetes mellitus with mean values of age, BMI and weight being 62, 29kg/m2 and 81Kf were selected after informing them about the procedure and probable results of the experiment and obtaining their written consent. It was ensured that the Diabetes patients were reasonably controlled and were on a treatment procedure involving the drugs sulfonylurea, and a combination of sulfonylurea and metformin; which was continued during the period of experiment.

Each of the participants was provided with instruction booklet to ensure that the other conditions are maintained uniform during the course of the experiment. TREATMENT The patients were given two categories of treatments; one gelatin capsule with 3g ginseng given either 40 minutes before a glucose intake of 25g of 300ml glucose or simultaneous with same concentration of glucose; both taken orally. The control treatment involved identical administration of all ingredients as in treatment group except ginseng being replaced by a placebo capsule containing corn sugar instead of ginseng.

Four treatments, two tests and two controls were given to each participant in random order. PROCEDURE Maintaining every other condition of diet, activity and medication constant, participants were administered the above doses at intervals of 1 week after 10-12 hours of fasting in the morning. Each test was preceded with regular check up and complete dose of routine