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Atomic Force Microscope - Coursework Example

This paper summarizes, and reviews the three articles with a focus on how the authors were successful in achieving what was intended. In the first article, by Anshu Bagga, Mathur, Geoge, Monty Reichert, and Tuskey, experimental design and the quantitative method techniques were employed in conducting research. They made use of quantitative method in justifying their findings. In trying to establish how force transmission in endothelial cells is achieved, for instance, the authors utilized the Atomic Force and the Total Internal Reflection Fluorescence microscopy. The authors did this by mounting a bioscope AFM on an inverted microscope. Then they contacted an experiment for Variable-angle TIRFM. This was meant to help calibrate the coupling angle using the depth of penetration of the evanescent wave. They collected the set of force curves on the whole cell surface to help them in measuring the cellular mechanical properties. Using the linear regression fit for the force indentation curves, they were able to find the elastic modulus for the nuclear, cell body that was in proximity to the nucleus, and for the cell body that was near the edge. ...
When they removed the force from the nucleus, they found that the focal contact area significantly increased. The focal coverage area did not significantly change before and after applying the force over the edge. In conclusion, the authors were able to meet their research objective, which was meant to ascertain the transfer of localized stress

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from apical to the basal surface, thereby leading to rearrangement of contacts along the basal surface. However, just like in any other experiment, the authors of this article had a ray of problems. For example, it was challenging for them to calculate the exact modulus because of faultiness of the Hertz model. More disturbing to the authors was the experiment for ascertaining the change in the contact area and relaxation of the focal contact within the first five minutes because of viscous relaxation of the cell, which they feel might have altered the results of the experiment. Since they were dealing directly with the skeleton, it was expected that they show how the cytoskeleton directly contributes to the force transmission. Unfortunately, this was not the case. There are outstanding shortcomings of this research article as far as the validity of its data is concerned. In any standard research it is expected that Claims about Results, as well as Implications are supported by Data (Njihia 23). In this article, this is not the case. When the researcher failed in finding the correct value of modulus, which is an important factor as far as the research is concerned. He gets wrong results, which do not amount to concluding that the materials were elastic to justify his modulus values. He is only keen at using other research literatures to support his assertion making


Name Institution Date Article Review The article by Anshu Bagga, Mathur, Geoge, Monty Reichert, and Tuskey deals with the study of force transmission in endothelial cells using the Atomic Force and the Total Internal Reflection Fluorescence microscopy. The objective of the article was to examine the transmission of force from the cell membrane of the apical cell to the cell membrane of the basal cell…
Atomic Force Microscope
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