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Heavy Metal Lead (Pb) and Cadmium (Cd) Cytotoxicity Assessment in Newborn Rats - Research Paper Example

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this paper 'Heavy Metal Lead (Pb) and Cadmium (Cd) Cytotoxicity Assessment in Newborn Rats" focuses on a cytotoxicity of the heavy metals lead and Cadmium on the activity of the antioxidant enzymes catalase and glutathione peroxidase, and the biomarker malondialdehyde. …
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Heavy Metal Lead (Pb) and Cadmium (Cd) Cytotoxicity Assessment in Newborn Rats
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Download file to see previous pages The purpose of this study was to assess the cytotoxic effects of prenatal and perinatal exposure to the environmental metal toxins, cadmium and lead, in rat pups. Data obtained from this type of study may be useful in assessing the potential cytotoxic effects of metal exposure in humans at early stages of development. The specific aims of this research study were to evaluate the effects of metal exposure on (I) tissue catalase activity; (ii) the comparative levels of glutathione peroxidase activity at parturition and at weaning in pups exposed to cadmium postnatally; and (III) on the levels of malondialdehyde at weaning. These tests were performed on blood samples and brain tissues obtained from rat pups on the day of parturition (Day 0) and postnatally at weaning (Day 21).
Toxic metals cadmium and lead constitute important environmental pollutants that are found in contaminated water, air soil, manufacturing products and certain foods. These redox-inactive metals cause oxidative tissue damage by decreasing the levels of antioxidants in the body and also antioxidant enzymes, especially by means of interacting with their critical sulfhydryl SH groups (Ercal et al, 2001). These toxic metals induce the formation of hydroxyl radicals (OH-) and superoxide radicals (O2-) and peroxide (H2O2). Oxidative stress occurs in response to the elevated production of these highly reactive oxygen moieties and may result in the depletion of critical anti-oxidant enzymes necessary for free radical inactivation. Lipids, proteins and DNA structure can be directly affected by free radicals in the cell, resulting in significant physiological damage. The production of oxidative stress by these metals appears to be a significant cause of their cytotoxic effects in the body (Ercal et al, 2001).
A great deal of experimental evidence indicates that exposure to environmental toxins, lead and cadmium, may have serious consequences on neural development and multiple organ system functions.   ...Download file to see next pagesRead More
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