Biochemistry science field - Research Paper Example

Therefore, it may be hypothesized that the use of cartilage in the promotion of endochondral regeneration of bones may leverage normal development and repair sequences resulting in a properly vascularized regenerate capable of integrating with the host tissues. Various tests have demonstrated that cartilage grafts are able to support the regeneration of vascularized and integrated bone tissues in vivo, while lineage tracing experiments have revealed graft derived regenerates. Mesenchymal stem cells are actually the pluripotent cells existing in numerous adult human tissues, for example bone marrow and adipose as well as synovial tissues, and since they originate from the mesoderm, they differentiate to become bones and cartilage as well as muscles and adipose tissues (Nolta, 2006).

Mesenchymal stem cells from embryonic sources have demonstrated probabilities in science while at the same time creating a considerable amount of controversy. As a consequence, numerous researchers have put emphasis on adult stem cells or those isolated from human adults that may be transplanted in to tissues that are damaged. As a result of their multi-potent capability, mesenchymal stem cell lineages have been employed with success in animal models in the regeneration of articular cartilage and in human models in the regeneration of bones.

Research done recently has shown that articular cartilage can be repaired through percutaneous introduction of mesenchymal stem cells. This paper aims at explaining how bone and cartilage can be differentiated from stem cells as well as considering the current research and development of this discipline. An experiment that sought to investigate conditions that can stimulate stem cells to differentiate into fat of bone cells while being encapsulated by hydrogels was conducted with polymer networks, which could simulate various conditions where the stem cells grow naturally.

The first step in growing the new cartilage involved initiating