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Microtubules - Lab Report Example

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This insinuates that Clip accumulation is dependent on EB1 presence, especially with the acidic tail in question. The binding action…
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Download file to see previous pages This interaction, revealed by the structure, is branded the EB1-like motif and there is possibility that the binding interaction of CLIP family depends on this. Intuitively, considering that CLIP experiences binding at the acidic tail of tubulin, it is also possible that the acidic tail of EB1 also provides the same condition allowing for binding. 12
One of the important parts of the cell micro skeleton is the microtubules. The dynamics of microtubules is a very significant feature of cell control and cell morphogenesis. According to research carried out recently, microtubules are attributed with the role of maintaining intrinsic cell length control. Meanwhile, even after the development of a model that describes the MT dynamics that are associated with the control of cell length, elucidation of the spatial variability of MT nucleation is yet to occur.
This presentation is a case of an investigation on the dynamics that are associated with nucleation of microtubules. This presentation particularly refers to a Hela cell that has no visible chromosome which was videoed after aligning itself along a track of micro patterned fibronectin. This presentation also wanted to find out the quantitative distribution of catastrophes and velocities inside the cell’s cortical and non-cortical regions. It also sought to investigate the spatial distribution of the microtubule nucleation that had resulted.
According to the results obtained, concentration of microtubule nucleation could not be considered random as it was concentrated in particular regions of the cell. Also, the results showed that the cortical actin was instrumental in triggering the nucleation rate. The rate slowed down after the cortical actin layer was removed. After further examination of the microtubule lifetimes among the case and the control, it was found out that the slowing of nucleation rate could be attributed to the slowing down of the microtubule catastrophe rate, in the ...Download file to see next pagesRead More
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