Beneficial Effects of a Novel Rage Inhibitor - Essay Example

Analysis of Beneficial Effects of a Novel RAGE Inhibitor on Early Diabetic Retinopathy and Tactile Allodynia
The topic of retinopathy and the working of RAGE inhibitors is discussed briefly, initially and this brevity appears not commendable because the readers may require a thorough introduction to the topic in order to understand the whole article and to develop interest from the very beginning. Various researchers investigated RAGE inhibitors as the pathogenesis reasons for causing diabetic impediments and the authors of the article have incorporated that knowledge in the introduction to make it strong. However, the shortness of the introduction is a drawback of the article. The research of previous studies that the authors include does not inform about the harmful consequences of RAGE inhibitors on diabetic patients that should also be a part of the study. As far as the language and style acquired by the authors are concerned, they are quite explicit and easy to understand.
The objective that the authors introduced in the abstract was followed in the whole paper and the content was linked. The medical students will have no problem in understanding the article because of the simple and explicit language. Anyone having less knowledge of the subject will also be able to understand the article because of simple language. The hypothesis of the research is that diabetic patients are benefitted because of RAGE inhibitors. The authors included arguments and discussions backing their stated hypothesis.
For conducting a study, the researchers are required to use different methodologies in the study to come up with a conclusion. Likewise, this study also makes use of three methodologies that are the inclusion of experimental animals, ‘diabetes-induced retinal histopathology’, and neural retina getting outflow of albumin that gets leaked. The methodologies used by the authors are not used but also elaborated so that the readers can know about them in detail. The authors also took notice of descriptions regarding the usage of methodologies such as the male rodents used in the research to keep sex-related research quite separate. For getting reliable results, the researchers used samples for the study. For getting information about the outcomes of using diversified RAGE inhibitors, the authors used three divided doses to come up with a conclusion that different RAGE inhibitors do not affect diabetic patients differently.
Statistically, the analysis techniques of ANOVA and Fischer, both were used to get satisfying results. The statistical analysis was done in a sequential manner that was supportive of following the calculation of data. However, when the results are seen separately, they are given in a haphazard manner and different results are not given separately due to which, readers have problems in understanding them individually. Graphs are also given that are based on calculated data. The authors have used a graphic representation of data that is a positive point. Graphs inform about wider data in a small space. Therefore, as far as the results section is concerned, it is averagely presented and requires a little improvement.
The authors did not forget to include their hypothesized statement in the conclusion and discussion section. They do not take support of wordiness, but just stated explicit facts and figures with elaborative arguments about their research. The discussion was understandable and clear and the authors connected their results with previous research. Read More