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Evaluate the evidence that regulatory T cells maybe be successfully used to prevent graft versus host disease - Research Paper Example

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Graft versus Host Disease (GvHD) is an immunological response to what the human body recognises as foreign proteins delivered into the body by transplantation. It has been researched and experiments have been carried out to determine whether a certain subsets of regulatory T…
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Evaluate the evidence that regulatory T cells maybe be successfully used to prevent graft versus host disease
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"Evaluate the evidence that regulatory T cells maybe be successfully used to prevent graft versus host disease"

Download file to see previous pages A main immunological technique that is used to measure regulatory T cell frequency is flow cytometry; other methods used are immunohistochemistry staining involving studying skin biopsies and ELISAs. All evidence proved strong in correlation with the hypothesis and suggests that CD4 CD25 FOXP3 Tregs could provide a future for the treatment of GvHD.
Transplantation is the process of obtaining tissues or organs or cells and placing them in the same or different individual. The organs, tissues and cells that are transferred from one individual to another are called grafts. The person who donates the graft is called donor and the one who recieves the graft is called recipient. Heart, kidney, cornea, liver, pancreas, lungs and bone marrow are transplanted from one person to another. There are two types of transplantation: autograft (transplant from one region to another of the same indivudual and Syngraft or Isograft (Transfer of graft between individuals of same species). ( Khan, 2009).
Graft versus host disease is the series of events that occurs after the transplantation of the donor T –cells with the stem cell graft. This is a donor T-cell mediated syndrome where the T cells in the graft shows their immune response. This response creates tissue damage. ( Beres and Drobyski, 2013). This is the major difficulty after the stem cell transplantation. The T-cells can recognise the minor and major histocompatibility antigens that are expressed at the host antigen presenting cells. The T-cells gets activated and expands and finally infiltrates and destroys the Graft versus host disease target tissues. The major tissues targeted are liver, gut and skin. This graft versus host hematopoiesis effect is the target for the allogenic stem cell transplantation. (Edinger, 2009). The rejection of the host may occur in first 100 days, where the donor immune cells recognize and attack the host tissues. As ...Download file to see next pagesRead More
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