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Brainscapes Resolution Template - Case Study Example

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Sodium magnetic resonance imaging (MRI) has been used to assess the metabolic changes that ensue from loss of cell ion homeostasis due to cell death in the…
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Brainscapes Case Resolution Template
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Download file to see previous pages he sodium concentration detected from MRI of the hippocampus suggest that the neurons in the hippocampus became diseased and were not functioning properly? What sort of a change in the Na+ concentration gradient would you expect when neurons are damaged or malfunctioning?
In a normal brain tissue, the large intracellularcompartment maintains a low sodium concentration( ~10mmol/l) against a high sodium concentration in the extracellular compartment(~140mmol/l) After the death of neural cells,the intracellular space of a cell shrinks and the extracellular space increases. The larger concentration of sodium in the extracellular space yields a larger sodium signal intensity.
3 In addition to the information in the case presentation (including the web sites contained in the case itself, what other information did you find to determine whether the differences in Na+ concentrations in hippocampal cells could be related to changes in memory function? Where did you find this information?
There is considerable evidence to suggest that the hippocampus and the related medio-temporal lobe structures of the human brain are crucial for the encoding and storage of information in long term memory
4) What does each of these additional items contribute to the solution of the case? For example, the item contains data from specific tests, trials, or experiments, or presents analyses that canbe used to understand the main issues in this case.
The Thulborn study has provided evidence for the changes in sodium concentration upon death of neural cells. These have enabled the use of sodium magnetic resonance imaging to determine the sodium levels in hippocampus to test for the presence or extent of AD.
There may be situations where the sodium content may increase in cells that are not dead or degenerated thus giving a false interpretation of the results. Increased sodium in the tissue could be caused by direct leakage of sodium because of amyloid beta channels in membranes ...Download file to see next pagesRead More
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