Analysis of Multilevel Regulation of the Circadian Clock by Cermakian and Sassone-Corsi - Article Example

The work aims to describe and illustrate in detail the general concepts that built the foundation of animal circadian clocks. It has been conceptualized by previous studies that several clock functions and characteristics have been conserved during evolution at the transcriptional level but some detailed functions of the loop may somewhat differ from organism to organism. For instance, the feedback loop functions differ among the Drosophila fly, mammals, fungi, and bacteria. Thus, these differences among organisms have led the authors of the article to study other levels of regulation of circadian clocks among organisms.

Cermakian & Sassone-Corsi found out that contrary to the only role of the input gene products to oscillation, there are some important input and output genes to achieve effective pacemaker function. The work of the researchers also revealed that despite the similarities between the fly and mammalian circadian systems, there are also differences in the negative limb of the loop (Cermakian & Sassone-Corsi, 60). In addition, the work of the researchers also found the existence of inter-genic and intragenic loops and that rhythms are not only generated at the transcriptional level but at multiple levels.