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The article entitled “Multilevel Regulation of the Circadian Clock” by Nicolas Cermakian and Paolo Sassone-Corsi discussed in detail the biological explanation of circadian rhythm and how its clock (circadian clock) is being regulated at multiple levels. According to the…
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Download file to see previous pages regulated at the transcriptional level but also in the post-transcriptional level, post-translational mechanisms, chromatin remodeling, clock proteins availability, and intracellular localizations (Cermakian & Sassone-Corsi, 61).
The work aims to describe and illustrate in detail the general concepts that built the foundation of animal circadian clocks. It has been conceptualized by previous studies that several clock functions and characteristics have been conserved during evolution at transcriptional level but some detailed functions of the loop may somewhat differ from organism to organism. For instance, the feedback loop functions differ among the Drosophila fly, mammals, fungi and bacteria. Thus, these differences among organisms have led the authors of the article to study other levels of regulation of circadian clocks among organisms.
Cermakian & Sassone-Corsi found out that contrary to the only role of the input gene products to oscillation, there are some important input and output genes to achieve effective pacemaker function. The work of the researchers also revealed that despite the similarities of the fly and mammalian circadian systems, there are also differences in the negative limb of the loop (Cermakian & Sassone-Corsi, 60). In addition, the work of the researchers also found out existence of inter-genic and intragenic loops and that rhythms are not only generated at transcriptional level but to multiple ...Download file to see next pagesRead More
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