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Medical Genetic - Essay Example

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Maternal transmission of diabetes is above that of the paternal to the offspring. Several environmental and genetic factors explain the exceeding transmissions of IGT and IFG by the mother. Factors like mitochondrial inheritance, behavioural risks and genetic imprinting are…
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Medical Genetic
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Download file to see previous pages Offspring with diabetic father and those with diabetic mother show negligible difference in symptoms save for the high LDL-cholesterol identified in those with diabetic mothers. On the other hand, children with diabetic mothers have low hypertension prevalence than those with diabetic fathers.
If II: 2 is heterozygous, her genotype will be Mm. III: 1 will be heterozygous in that situation. Looking at how diabetes fulfils the criteria in maturity-onset diabetes of the young (MODY; 613370), Edghill et al. (2008) indicates heterozygosity transmission in a third generation family with three members affected.
7. Yes. Studying the historical nature of the Maturity-Onset Diabetes of the young, it is indicated that patients may not show symptoms of the disease and that diagnosis may be made only when they reach old age. This is because the onset of diabetes, whether, genetic like in this case can be inhibited by the youthful active nature. Youths are very physically active and this can possibly regulate the onset of diabetes.
8. This is a transverse reaction. The amino acids changed because there was a deletion of the TTC trinucleotide in there codons. This is a non-conservative substitution reaction whereby Gly 148 (GGG), which is considered normal, becomes Arg148 (AGG).
9. DNA replication may be affected by strand slippage or crossover events which are unequal. Repetitive sequences at the misalignments cause deletions and nucleotide addition to the molecules of DNA. During substitution, there will be 1 DNA molecule holding a deletion and one having an insertion. The events above occurs when the mismatch repair mechanism fails, failure of direct repair, and nucleotide-excision repair.
5. This is a Mendelian inheritance.For a trait to be Mendelian, the child that receives the allele that is dominant from either of the parent has to have the trait that is dominant in form. The possession of the phenotype that is recessive occurs only when ...Download file to see next pagesRead More
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