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Calmodulin - Article Example

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Calmodulin is a protein which is referred to as a “calcium binding protein” and this protein is known to be present in both animals and the plants. The protein comprises of 148 amino acids and it possesses four sites which are referred to as “domains” where calcium can…
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Download file to see previous pages Calmodulin possesses a very important function of stimulating the functioning of different enzymes as well as the mediation of ion channels. The activity of calmodulin is only brought about by the attachment of four calcium ions. This attachment brings about a change in the structure of calmodulin and makes it capable of performing its functions. The withdrawal of calcium ions from calmodulin restores it to its inactive state. The different enzymes that work after being activated by calmodulin include adenylyl cyclase, calcium magnesium ATPase, nitric oxide synthase, phosphorylase kinase, calcium dependent protein kinases and calcium phospholipid dependent protein kinase. It also possesses the function of acting on certain receptors like NMDA-type glutamate receptor as well as on ion movement pathways which include L-type calcium channels. Calmodulin also has an effect on other cellular mechanisms. The contractility of smooth muscle is one such function. In cells that are non-contracting, calmodulin has an effect on the motile activity of the cells and other processes like mitosis. The wide ranges of functions that can be performed by calmodulin clearly explain the importance of this protein in the living organisms. Its malfunctioning can result in hampering the activity of many enzymes, ion pathways and affect other regulatory processes (Champe et al 2005; Murray et al ...Download file to see next pagesRead More
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