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The effect of Salbutamol on the response of Ileum to Acetylcholine - Essay Example

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From the graph, the EC50 of Acetylcholine is 4.00E-08, while the EC50 of Salbutamol + Acetylchline is 4.00E-08. The values for the Ec50 of Nicotine are 5.5E-06, and the EC50 OF Salbutamol + Nicotine is 5.00E-06…
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The effect of Salbutamol on the response of Ileum to Acetylcholine
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Download file to see previous pages This clearly implies that there is no significant effect of sulbutamol on the way the ileum responds to acetylechline. However, there is a significant effect of the sulbutamol on the way ileum responds to nicotine. This desensitisation was purely characterised by increasing values of EC (50) of nicotine without a change in its maximal effect. This thus implies that treatment of ileum with salbutamol after exposure to the acetylcholine, had little desensitisation while treatment of ileum with salbuamol after exposure to nicotine caused some larger increase in the Nicotine-mediated phoshoinositide hydrolysis. Response to question 2. Salbutamol could be referred to as an adrenergic agonist receptor, which is used to reduce the effects of bronchospasm in diseases like asthma. It is also used in the treatment of cystic fibrosis, pulmozyme, acetylcysteine, and iprptropium that is linked to DOK-7. As an example of a beta2-agonist, sulbutanol can also be used in obstetrics. The salbutamol that is intravenous could be utilised as a tocolytic in relaxing the smooth muscles of the uterus, and hence delay premature labour. This has made sulbutamol be the most preferred agent. In the context of this experiment, salbutamol antagonist’ caused a parallel shift of the given dose response curve. ...Download file to see next pagesRead More
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