Sickle Cell Disease Name University Sickle Cell Disease Sickle cell disease refers to a group of disorders among which sickle cell anaemia is the most common. It is an inherited disorder of blood and hence it is not contagious. Sickle cell disease is a gene-related disorder so it tends to run in families and those who do not carry the genotype of the disease, are at no risk of getting it ever in life…
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Due to the abnormal haemoglobin formation, this oxygen delivery is affected. The red blood cells also lose their normal functional capacity and acquire a sickle shape and this leads to anaemia in the patient. These individuals are also more prone to infections (Bloom 1995; Govan et al 1995; Ganong 2005). The image above shows the difference between the normal shaped red blood cells and the red blood cells of sickle cell disease (National Heart Lung and Blood Institute 2011). Each parent contributes to the genetic makeup of an individual. Half of the genes are inherited from mother and the other half from father. Some traits are completely governed by the type of genes present in the body like colour of eyes and height while others may be influenced by the environment like athletic abilities. Although the parents make an equal contribution of genes but their effect is not always the same. Some genes are dominant and some are recessive. The dominant gene produces its effects in all cases while the recessive gene has to be present in a pair to produce the desired effects. HbS which is the gene implicated in the causation of sickle cell disease is a recessive gene. ...
ase If one parent is diseased and the other is normal If both the parents are carriers of the defective gene If one parent is carrier and the other is normal Both the parents are neither carriers nor do they suffer from the disease The chance of transmitting the disease is 100% in the case when both the parents of a child suffer from sickle cell disease. If one parent is diseased and the other is carrier of sickle cell trait, the chance of developing disease is reduced to 50% and if one parent is diseased and the other is normal then there is 0% chance of disease development however it will produce sickle cell traits in the children (Bloom 1995). The figure above shows the “Genetic pedigree” of sickle cell disease.( Shiverdecker 2005) The clinical manifestations of sickle cell disease vary with the age. The major complication associated with the disease is chronic low levels of haemoglobin while some other complications include bacterial infection, splenic sequestration while stroke, renal disease, pulmonary hypertension, leg ulcers depict the organ damage in long standing disease. The infection from bacteria results from the reduced functioning of the spleen or asplenia. Asplenia occurs due to the continuous destruction of sickle shaped red blood cells in the spleen which results in the affecting the normal functional capacity of the organ. Hence, spleen is the first organ to be damaged. Splenic sequestration is characterized by the enlargement of the organ and decreased Hb levels along with thrombocytopenia present occasionally. This has been a common cause of death due to sudden circulatory collapse. Acute chest syndrome affect almost 50% of the patients and it is the second leading cause of emergency. Adults are generally more affected. In acute chest syndrome,
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(Sickle Cell Disease Research Paper Example | Topics and Well Written Essays - 1250 Words)
“Sickle Cell Disease Research Paper Example | Topics and Well Written Essays - 1250 Words”, n.d. https://studentshare.org/biology/1443703-sickle-cell-disease.
The article describes the condition of Ryan Clark, safety of Pittsburgh Steelers and the reason why he has been restricted from playing in the upcoming game against the Denver Broncos. The writer has described the limitations a professional player has to face because of sickle cell trait and has also highlighted the underlying pathology of the blood disorder.
The author claims that the dreaded complication of the disease in adults are infarction crises which can manifest as dactylitis, femoral head necrosis, hematuria and stroke. The disease is through autosomal recessive inheritance. Mutation of the HbS gene causes a different type of hemoglobin that causes sickling of red blood cells.
This study will be guided by the following research questions: What is the level of knowledge among pregnant women with the sickle cell trait from the Mississippi Delta about sickle cell disease? What are the attitudes of pregnant women with the sickle cell trait from the Mississippi Delta about sickle cell disease?
SCD is a genetic disorder with autosomal recessive pattern of inheritance (Pelehach, 1995; Routhieaux, Sarcone, Stegenga, 2005) caused by a single-based mutation of adenine to thiamine resulting in a substitution of valine for glutamine at the 6th codon of the ?
This paper take a look at some of the various ways that the disease affects the lives of people and how this disease can be controlled and managed without causing death. A series of articles and books have been used here as the main sources for getting the useful information used here.
Most pregnant women fear telling their husbands that they should go, be screened, and would rather give birth to children who have sickle cell anaemia. The contributory factor to sickle cell anaemia is the fact that most people lack education about the disease and so are not aware about it.
Research shows that one in 12 African Americans and about one in 100 Hispanic Americans convey the sickle cell attribute, which implies they are bearers of the infection. Sickle cell sickness is brought about by a change in the hemoglobin-Beta gene found on chromosome 11.
Around 70,000 people, who are from sub African, even though there are some reports in India, some parts of central and South American areas, southern parts of Europe, and Caribbean regions mostly experience sickle cell anemia. Several children do not show any
ife she has lived, her days of no pain are very countable, and my one greatest fear is that she may never make it to the age of 40 because of the long term effects and prognosis of the disease.
Sickle cell anemia is a non treatable hereditary problem which has an effect on the
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