Research Proposal Artificial Organic Heart – Treating Cardiovascular Diseases through Tissue Engineering and Regenerative Medicine By Your name University Affiliations Date Artificial Organic Heart – Treating Cardiovascular Diseases through Tissue Engineering and Regenerative Medicine Cardiovascular diseases and heart failure are the major ailments plaguing millions of humans worldwide…
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Even in those cases where patients have been able to afford such transplants, other problems such as organ rejection and incompatibility have deprived them of their precious lives. The gravity of this situation has led to unrelenting research on stem cells, tissue engineering, and regenerative medicine, which are promising and hopeful alternatives to organ transplants. By 2009, in the United States, about 50 million people had survived because of some or the other form of “artificial organ therapy” (Khademhosseini, Vacanti and Langer, 2009). This gives a clear indication that artificial organs are the hope of the future. This research proposal aims at providing a brief yet objective overview of how an organ can be fabricated by starting with single cells and proceeding to tissue replacement. The proposal is intended to explain how vital organs can be fabricated through bioengineering. The solutions for problems that are usually encountered during fabrication of living organs are also dealt with. Important challenges include optimization of the decellularization process for the preservation of vascular architecture and for limiting immunogenicity. Overall, this proposal gives a precis on solving cardiovascular diseases by stem cells, tissue engineering and regenerative medicine. Approach to organ fabrication 1. Procurement of stem cells The first step would be to procure embryonic stem cells that would act as progenitors for the cardiac cells. With the help of embryonic stem cells, it is possible to generate both mature cardiocytes as well as the vasculature (Ott et al, 2007). The most appropriate conditions for the growth of these stem cells will be identified and these will be allowed to grow, mature and differentiate before being seeded on a protein matrix for tissue formation. 2. Identification of suitable decellularization procedure for obtaining protein matrix The protein matrix for the generation of tissue and vasculature will be obtained from dead hearts procured from appropriate facilities. Using suitable detergents and chemical treatments, the organs will be decellularized to reveal the protein matrix. Various techniques will be tested before arriving at the most appropriate decellularization agent. 3. Seeding of the protein matrix with progenitor cells The protein matrix will then be seeded with the cardiocytes so that they can naturally develop into tissues and vasculature of a natural heart. Because of the provision of a natural protein matrix and scaffold material derived from a real heart, it will be easier for the cardiocytes to grow three-dimensionally through a natural mechanism. 4. Testing the functionality of the artificially produced organ The functionality of the manufactured heart will be tested and monitored for normalcy of pulse rate and other vital parameters. 5. Animal studies The artificially produced hearts will be transplanted into adult mice and will be tested for development of immunogenicity and health parameters. Possible Problems during Fabrication A major problem during fabrication of an artificial organic heart would be to achieve appropriate tissue vascularization having the vascular structure of a natural
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There is a strong emphasis put on innovation in today’s environment in order to enable firms to differentiate themselves as improved in both the service and the products they provide. However, organizations are consistently looking for better ways so as to innovate rapidly and effectively both within and beyond their product lines and central markets.
Tissue engineering, a concept that is still developing, broadly encompasses the creation of biological agents and the remodelling of specific body tissues or organs, in order to substitute, restore, regenerate or improve their functional effectiveness (Nerem and Ensley, 2004).
B) Describe the impact of neurohormonal activation on the progression of left ventricular dysfunction The most important pathways in the neurohormonal activation in the pathogenesis and progression of heart failure include the renin-angiotensin-aldosterone and the sympathetic nervous system.
Post Doctoral Research Proposal Novel Approaches in Tissue Engineering and Regenerative Medicine Tackling the Incidence of CVD by Your name University Affiliations Date Novel Approaches in Tissue Engineering and Regenerative Medicine Tackling the Incidence of Cardiovascular Diseases Cardiovascular diseases (CVD) are a growing cause of concern globally, mainly due to sedentary lifestyle encouraged by technology.
Stem cell research is controversial due to the debate surrounding the possible sources of stem cells - embryonic stem cells and adult stem cell. In this sense, the research will focus only on adult stems cells (ASC) and its potential. It asserts that ASC has to address the ethical issues surrounding it as it involves human subjects.
Study of tissue engineering is a multidisciplinary field encompassing specialities like clinical medicine and cell biology in addition to bio-materials technology (Ikada, 1999, p. 628). This emerging biomedical engineering has two advantages
Nanotechnology is still under development and it has a lot of potential in health care construction in areas such as gene therapy, diagnostics and drug transport (Koprwoski, 2012, p.157). Over the years nanotechnology has been thought of being a dream for
Name Instructor Course Date The Impact of Embryonic Stem Cells on Regenerative Medicine The new millennium has come along with it new developed in biomedical science. Since the human genome series was completed, it saw an advanced drug discoveries being manufactured and micro-assortments technology to measure millions of genes in single a research.
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