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Treatment of Unipolar Depression - Essay Example

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Trials were searched in computerized general (Medline, Psychlit, and Embase) and specialized databases (Cochrane Controlled Clinical Trials Register, Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trial Register); by checking reference lists of relevant articles; by handsearching relevant specialist journals; and by contacting relevant authors where appropriate
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Treatment of Unipolar Depression
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Download file to see previous pages Overall, 5-HTP appeared to be slightly better tolerated than fluvoxamine, although the results did not reach the level of statistical significance.
What personal interests and/or short or long term goals lie behind this - not strictly required for a proposal but it is usually helpful to think this through as it can help you focus [one paragraph]
What aspect(s) of theory / knowledge is/are behind this What are the gaps in the research or what parallels are there in adjacent fields (ie a short literature review to set up the purpose and question) - 5-HTP has also been compared in a few studies with conventional tricyclic antidepressants (chloripramine and imipramine) - the most effective drugs for treating depression until the development of the SSRIs. The studies found 5-HTP to be at least as effective as these drugs in treating severe depression, while displaying fewer side effects. In severe cases, 5-HTP dosages as high as 1200 mg daily were used
What objectives, steps, sub-questions, angles of inquiry or sections of your paper would you break your question or inquiry aim into - CCDANCTR-Studies was searched (carried out on 12/1/2005) using the following search stategy (Diagnosis = Depress* or Dysthymi* and Intervention = tryptophan or 5-htp or 5-hydroxtryptophan or Hydroxytryptophan and Intervention = Placebo). Reference lists, book chapters and conference proceedings were checked. Experts and triallists were contacted for unpublished studies

Section B -Study design and method / methodology
What type of study would help with your question and focus
Please bold underline to identify It is OK to use "other" and briefly explain - but otherwise no explanation required here. You should read up on these if you don't know what they are, but we assume you know what the one you pick is)

case study
reflective self-study
academic paper2
other - please identify
take advice

Why / how will this design work with your question and focus - Trials were included if they were randomized, included patients with unipolar depression or dysthymia, compared preparations of 5-HTP or tryptophan with placebo, and included clinical outcomes assessed by scales assessing depressive symptoms

take advice

If you intend to use a particular methodology, briefly explain how it works and why you want to use it. - Eg - reflective self study, controlled trial, grounded theory, ethnography. This must be appropriate for the way you have worded your research question / inquiry. Please note that it is not essential that you have this for an undergraduate project. For an academic ...Download file to see next pagesRead More
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