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On OSTEOPETROSIS - Research Paper Example

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Osteopetrosis Introduction Osteopetrosis is a clinical syndrome that is characterized by failure of the osteoclasts of the bones to resorb bone tissue, resulting in failure of bone modeling and remodeling. This ultimately leads to skeletal fragility, hematopoietic insufficiency, disruption of tooth, entrapment of nerves and impairment of growth (Bhargava, and Griffing, 2009)…
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Research paper on OSTEOPETROSIS
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Download file to see previous pages... Mortality associated with infantile osteopetrosis is high. Those with adult osteopetrosis have longterm survival chances. In this research essay, the pathophysiology, clinical presentation, investigations, treatment and prevention will be discussed. Purpose The main purpose of the paper is to present an overview of osteopetrosis. Pathophysiology The main defect in osteopetrosis is in osteoclast which belongs to monocyte-macrophage lineage and genetic defects leads to abnormal osteoclasts (Tolar et al, 2004). Osteoclasts are very important in the modelling and remodeling of the tissue of the bone and defective osteoclasts fail to model and remodel the bone appropriately, resulting in abnormal encroachment and deposition of bone tissue (Teitelbaum, 2000). The abnormal bone tissue is susceptible to fractures and can encroach into the bone marrow leading to bone marrow failure. it can also encroach around the nerves causing nerve entrapment syndrome. When blood vessels are affected, ischemia, especially of the bones like mandible can occur. Eventually, the patient develops multiple fractures, anemia, bleeding disorders and sepsis (Bhargava, and Griffing, 2009). Clinical presentation The clinical presentation depends on the type of osteopetrosis. ...Download file to see next pagesRead More
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