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This causes blood to accumulate compressing the brain. There are two types of haemorrhagic strokes. Which include intracerebral, and subarachnoid categorized based on the disease aetiology (Ewan et al. 2010).
Ischemic Cerebrovascular Accident is caused by the interruption of blood supply to the cerebral tissue. It has multiple etiologic mechanisms and clinical manifestations. The ischemia is caused by thrombosis, embolism, arterial luminal obliteration, venous congestion and systemic hypoperfusion (Laredo et al. 2011). An Ischemic thrombotic stroke is caused by the development of a clot that obstructs the blood vessel. Pathology in the local endothelium is the common trigger of thrombosis. The most common pathological feature of vascular obstruction is the chronic inflammation disease Atherosclerosis.
Atherosclerotic plaques usually form at bifurcation points of vessels and high shear stress points. They overexpress plasminogen activator inhibitor-1 that inhibits the enzyme plasminogen activator, which converts plasminogen to plasmin that degrades plasma proteins (Jorge et al. 2010). Plasmin is essential in fibrinolysis. Therefore, inhibition of activation promotes the formation of blood clots. Endothelial surface injury triggers an inflammatory reaction recruiting cytokines and peroxides. These substances trigger the expression of P-selectin, E-selectin and intercellular adhesion molecule-1 by the endothelial cells molecules necessary for the adhesion of recruited leukocytes to the endothelial wall. They migrate into the intima forming a fatty streak that are then infiltrated by macrophages forming plaques and accumulating lipids to form foam cells (Santos et al. 2012). Plaques can enlarge and occlude blood vessels, become ulcerated, calcify, develop thrombosis, form embolus or lead to the formation of an aneurysm. Ulceration occurs when the atherosclerotic plaques
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Advanced Pathophysiology What is the pathophysiology basis for the signs/symptoms and lab results that are seen in this case? The patient has a white blood cell count of 250 000 which higher than the normal of 3500-10500cells/mcL (Harrison, 2011). Understanding the pathophysiology of this lab result requires a further insight on the definition of ALL which is a cancer located in the bone marrow and blood affecting the WBC and is associated with the presence of immature lymphoblasts which do not mature to become lymphocytes.
His temperature was 42 irregular. There was also a history of alcohol abuse.
The construction worker was rushed immediately to the emergency and a quick assessment was made. The person was in a semi- conscious condition, but taking into consideration all the above facts of the person who had suffered a setback due to Haematemesis, we are able to understand that the individual was getting on in age and the pressure of his job was more than he could handle.
Obesity, poor diet, and lack of exercise are precursors to this condition. Fortunately, these factors can be changed.
In order to diagnose myocardial infarction, a series of tests need to be conducted—giving the patient a work-up which may
He becomes fatigue and tired even after a small walk. There is no case of hemoptysis or night sweats and chills. He also suffers from ankle edema. History revealed he had no incidences of asthma, childhood respiratory problems or allergies. He had acute
It is important to note that paramedics provide medical care for trauma and emergency situations. In this regard, accurate pathophysiology diagnoses is therefore very important to ensure effective treatment or
The brand name is therefore Myleran while the generic name is Busulfan. I will be looking at the drug’s pharmacology and therapeutic importance.
In terms of classification Busulfan is an organic sulphite i.e. contains
It can sometimes turn into a severe condition that poses a risk to the life of the patient. This condition affects the thyroid production that is important for the maintenance of hormone balance. These hormones handle the moods that humans project as
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