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Coronary Artery Disease - Research Paper Example

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Coronary Artery Disease or CAD is known as Coronary atherosclerotic heart disease has emerged as one of the leading causes of death in males as compared to females. Its progression constricts the extension of blood vessel leading to myocardial ischemia. Therefore, CAD results in…
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Coronary Artery Disease
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Download file to see previous pages It is established that LDL or Low-density lipoproteins are chiefly atherogenic in nature. On the other hand high-density lipoproteins or HDLs are defensive lipids as they aid in LDL metabolism. On oxidation LDLs become tougher to metabolize and become cytotoxic leading to endothelial injury (Pollard, 2009).
Chronic Endothelial injury Hypothesis- Endothelium protection and its repair is performed by glycosaminoglycan or GAGs, when GAGs become weak, atherosclerosis is instigated. The process is promoted due to exposure of endothelial cells and free-radical damage. As damage of endothelial lining is initiated the site promotes the permeability of plasma constituents especially the lipoproteins. Thus oxidized LDLs are capable of damaging the endothelial lining of the cells which results in the formation of plaque (Stephen, 2011).
When the endothelial cells are injured, the macrophages present in the blood move around from the blood circulation. The inner side of the artery forms a layer called layer of intima. Consequently, smooth muscles join intima along with connective tissue as well as lipids present inside as well as outside the cells to generate a plaque. This brings about union as well as accumulation of platelets, as well as release various growth regulating factors to amplify the procedure ensuing obstruction of the lumen of the artery, leading to thrombus establishment (Mottillo, 2010).
Mottillo, S., Filion, K. B., Genest, J., Joseph, L., Pilote, L., Poirier, P., Rinfret, S., Schiffrin, E. L., Eisenberg, M. J. (2010). The Metabolic Syndrome and Cardiovascular Risk: A Systematic Review and Meta-Analysis. J. Am. Coll. Cardiol, 56(14), 1113- 1132.
Stephen D. Wiviott, Marcus D. Flather, Michelle L. ODonoghue, Shinya Goto, Desmond J. Fitzgerald, Fernando Cura, Philip Aylward, Victor Guetta, Dariusz Dudek, Charles F. Contant, Dominick J. Angiolillo, Deepak L. Bhatt. ...Download file to see next pagesRead More
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