Experimental and Treatments of Sickle Cell Anemia - Essay Example

"Experimental and Treatments of Sickle Cell Anemia" is a perfect example of a paper on the cardiovascular system. Sickle cell disease is attached to several inherited disorders where the red blood cells distort taking a sickle shape (Mark, 2005). The disease commonly associated with congregating issues that impact hemoglobin, the particle in red platelets that transports oxygen to cells all over the body. The cells get early death which declares a shortage of the healthy red cells in the body thus causing a blockage in the blood flow causing pain majorly associated with sickle cell crisis. Researchers have given numerous approaches on how to treat sickle cell disease by implementing the bloodstream and reduce the number of red platelets which are found in the body's veins. Further procedural treatments suggest that sickle cell disease can be treated by inhibiting polymerization in mutant hemoglobin to form fibers (Li, X et al., 2016). The new method strained to delay the polymerization period, in these positions allowing more cells to outflow before fiber arrangements. The approach found a predominant deterrent of polymerization that develops cell volume, which thus lessens the merging of intracellular hemoglobin

The common type of inheritance can be referred to as autosomal recessive making the gene among the very first 22 pairs of chromosomes which do not necessarily determine the gender but rather affecting each sex to the same extend. A diagnosis on the sickle cell tests the defective nature of hemoglobin which triggers sickle cell anemia (Li et al., 2017). The suggested test is a routine check-in in the United States for newborn screening which also allows testing for older children and adults too. The test done on adults is through a blood sample that is drawn from one’s vein in the arm the make the necessary diagnosis. The nature of sickle cell disease is that it can be developed later in your life if the hemolytic anemia is not inherited.

Treatment of sickle cell disease targets to eliminate the common episodes of pain in the sickness where symptoms are relieved thus preventing further complications. The known treatment for sickle cell disease is medications and blood transfusions where some teenagers receive stem cell transport as a form of cure to the disease. The sickle cell disease can be treated through gene therapy which consists of the transplant of hematopoietic stem cells to the affected individual. Gene therapy, as it may, has no historical achievement in the fix of sickle cell disease, and a total understanding of its drawn-out dangers is likewise lacking (Hoban et al., 2016). The deficiency is with regards to; these current issues for those endeavoring to edifice a clinical preliminary with a model parity of hazard and its advantages thereof. Ongoing studies are a subject with transfusion-dependent receiving LentiGlobin DP which have proven sustained countenance of the therapeutic hemoglobin and have displayed marked developments in clinical indications in a one-year post-treatment.

Hydroxyurea treatment upsurges the stickiness of the bloodstream in sickle cells. Lemon in his article differs stating that no scrutiny has yet discovered the impacts of hydroxyurea treatment on blood viscosity and red blood cell rheology (Connes et al., 2018). The current test was to examine the effects of one year of hydroxyurea treatment on blood rheology hematology and clinical profile in sickle cell anemia grown-ups. There had been considerable progress made in the gene therapy technique of treating sickle cell disease. The combination of the various methods of treatment gives an alternative and hope for the victims within all age brackets either by eliminating reducing or giving total treatment.