Analysis of the Clinical Embryoscope Data - Essay Example

Clinical Embryoscope Data Introduction The use of embryoscope in the world has become a major source of success in many of the multi-centre fertility clinics. The use of the embryoscope time-lapse system has been noted to have major benefits in the lives of many women, with an increase in implantation rates and pregnancy rates noted, as well as the reduction of loss during early pregnancy days. Such news prompts millions of researchers to examine the impact that this has in the pregnancy rates across the world and its significance in meeting the required standard evaluation procedures. The importance of this study will be to allow more women to benefit from the utility of the system in attaining the required level of treatment in the available fertility clinics. The clinical data attained will assist in determining whether more systems need to be created or whether the chances of improving clinical pregnancy rates are limited. Aim/ Problem Statement The main aim is to determine whether the use of embryoscope assist in improving the outcomes of reproduction compared to the use of other methods traditionally believed to have played a crucial role in creating a better reproduction outcomes. This will be based on the information attained from conducting a study on subjects undergoing similar medical aspects. Hypothesis Embryoscope is one of the best ways of establishing high pregnancy rates and will be essential in defining the way women in the future carryout their reproductive aspects. Research Questions i. How prevalent is the use of embryoscope amongst women? ii. Are there any complications for women? iii. Are the pregnancy rates higher? iv. Is it a safe way of approaching reproductive health questions? Literature Review Over the past few decades, efforts by clinicians to improve the embryo selection have intensified with different studies carried out to ensure that things take place as desired (Ciray, Aksoy, Goktas, Ozturk & Bahceci 2012: 894). The aim is to generate a new understanding of what makes embryo implantation successful, and the impact such cycles have in assisting reproduction systems (Pribensky, Matyas, Kovacs, Losomczi, Zadori & Vajta 2010: 534). The goal of studies in this field is mainly to establish whether the continued study and use of embryoscope has been found to have a better rate of success, or whether traditional outlooks have a better chance of dealing with the selection methods that are mainly noninvasive as the embryoscope is (Wong et al. 2010: 1119). Many studies have attempted to check on the growing trends amongst a variety of the fertility clinics and keep track of the women under these programs (Kirkegaard, Hindkjaer, & Ingerslev 2013: 740). The main aim is to check on their steps towards a successful reproduction rate, as well as evaluation methods to define the monitoring systems that work best for the health of women around the world (Dal Canto et al. 2012: 476; Freour, Dessolle, Lammers, Lattes, & Barriere 2013: 1946). The possibility of monitoring an embryo for 24 hours has been a development that countries and doctors appreciate because they understand how significant step this is in redefining healthcare and reproduction (Wolff, Fredrickson, Walker & Morbeck 2013: 1780). The important thing is to systematically define the quality and quantity of information required to assist in understanding the documentation processes needed to attain the intended results (Campbell, Fishel, Bowman, Duffy, Sedler, & Fontes 2013: 479). Such steps will be essential in also making an integral approach towards the assessment of other embryos once the system is adopted by a myriad of fertility clinicians. Many show that at least 20% of women have better responses compared to those who go for normal procedures (Conaghan et al. 2013: 415). Another 35.7% have a lesser propensity to experiencing early pregnancy. This shows more needs to be done to establish the main causes of high pregnancy causes and the refining needed to make the process easier for mothers across the world (Bontekoe, Mantikou, van Wely, Seshadri, Repping, & Mastenbroek 2012). Methods The study design to be adopted is a randomised trial with controlled subjects. It will include two groups with at 70 subjects each to get 140 participants all aged between 18 and 43 years. It will be a voluntary prospective study that will allow participants to get into the study based on their approval of the methods in place. The setting will be in a private in vitro fertilisation clinic in which the chosen participants will be notified of the intentions and the choice of the individuals based on the subject’s infertility and current undertaking of ICSI (intracytoplasmic sperm injections). The other group of controlled group will get their injections from the cultured embryos in the standard incubators and evaluation will start. Data will be tabulated by taking time to analyse the personnel efforts measured by the amount of time spent with lab personnel supporting the patients, clinical pregnancy rates based on sonogram results four weeks after embryo transfer, quality of embryos as measured by cell number as facilitated during the entire pregnancy period. The sonogram will be taken at the fourth week, while quality of embryos will be done after threes since transfer. It will be a quantitative study with SPSS being used to analyse the presented data. Tabulations will show the progress of the pregnancies, with the timeframe documented using charts and graphs. Timetable The study period will be from September 2015 to December 2016. The aim is to collect as much data as possible and take as much time to come up with conclusive results and analysis from the presented information. This will also provide time to collected pilot tests on those who already have undergone through the ICSI process and gauge the expected results from those that are successful. The period between September 2015 and January 2016 will be used to have both the pilot tests collected as well as schedule meetings with supervisors. These will be regular. Budget Costs The budget is estimated to be $100,000 spread out over the next thirteen months. Item Cost (in $) Transport 40,000 Documentation processes 30,000 Purchase of computers and tablets 10,000 Scientific books not available at the university library 10,000 Consumables 10,000 Total 100,000 Contingencies Nothing has been envisioned as going wrong, though the researchers are aware of the importance of meeting all the safety regulations required when undertaking such a study. A qualified medical practitioner will be contacted in case of any emergency or complications. Ethical considerations The process may be considered as intrusive by some. To deal with this, the participants will be assured of total confidentiality, as well as the importance of integrity in carrying out the procedures. All documents will be stored in a password-protected PC, with the researchers allowed to retrieve them based on precautionary measures. All considerations for their safety will be taken, and approval sought from the University’s research committee. References Bontekoe, S., Mantikou, E., van Wely, M., Seshadri, S., Repping, S. & Mastenbroek, S. (2012) "Low oxygen concentrations for embryo culture in assisted reproductive technologies", Cochrane Database Syst Rev, pp. CD008950. Campbell, A., Fishel, S., Bowman, N., Duffy, S., Sedler, M. & Fontes, C.F. (2013) "Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics", Reprod Biomed Online, vol. 26, pp. 477–85. Ciray, H.N., Aksoy, T., Goktas, C., Ozturk, B. & Bahceci, M. (2012) "Time-lapse evaluation of human embryo development in single versus sequential culture media-a sibling oocyte study,” J Assist Reprod Genet, vol. 29, pp. 891–900. Conaghan, J., Chen, A.A., Willman, S.P., Ivani, K., Chenette, P.E., Boostanfar, R. et al. (2013) "Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial", Fertil Steril, vol. 100, pp. 412–9. Dal Canto, M., Coticcio, G., Renzini, M., De Ponti, E., Novara, P.V., Brambillasca, F., et al. (2012) "Cleavage kinetics analysis of human embryos predicts development to blastocyst and implantation", Reprod Biomed Online, vol. 25, pp. 474–80. Freour, T., Dessolle, L., Lammers, J., Lattes, S. & Barriere, P. (2013) "Comparison of embryo morphokinetics after in vitro fertilisation-intracytoplasmic sperm injection in smoking and nonsmoking women,” Fertil Steril, vol. 99, pp. 1944–50. Kirkegaard, K., Hindkjaer, J.J. & Ingerslev, H.J. (2013) "Effect of oxygen concentration on human embryo development evaluated by time-lapse monitoring,” Fertil Steril, vol. 99, pp. 738–44. Pribensky, C., Matyas, S., Kovacs, P., Losomczi, E., Zadori, J. & Vajta, G. (2010) "Pregnancy achieved by transfer of a single blastocyst selected by time-lapse monitoring", Reprod Biomed Online, vol. 21, pp. 533–6. Wolff, H.S., Fredrickson, J.R., Walker, D.L. & Morbeck, D.E. (2013) "Advances in quality control: mouse embryo morphokinetics are sensitive markers of in vitro stress," Hum Reprod, vol. 28, pp. 1776–82. Wong, C., Loewke, K., Bosser, N.L., Behr, B., De Jonge, C.J., Baer, T.M. et al. (2010) "Noninvasive imaging of human embryos before embryonic genome activation predicts development to blastocyst stage", Nat Biotechnol, vol. 28, pp. 1115–21. Read More