Types of Arthritis - Essay Example

"Types of Arthritis" is an exceptional example of a paper on the musculoskeletal system.
As individuals age, their joint tissues tend to get less resilient to friction and their degeneration processes begin resulting in swelling, pain and at times the bones lose their rate of mobility. When this system fails, dynamism takes place in both the soft joint tissue and the other bones opposing the movement, and this condition gets commonly referred to as osteoarthritis, which is a form of arthritis (Moreland & Emery, 2003). Arthritis occurs in two main different forms; osteoarthritis and autoimmune arthritis.

In the case of osteoarthritis, the processes of wear and tear of individual bones and joints take place repeatedly. One important factor that can accelerate this type of arthritis, particularly for the knees and lips, is obesity. Individual joints have cartilage aligned along with them for the purposes of facilitating cushioning and synovial fluid to enhance lubrication of the joint when in motion. These tissues continuously break down and wear away generating arise of a bone spur, narrowing of the joint, joint inflammation, and continuous pain.

The second type of arthritis is autoimmune arthritis, also called rheumatoid arthritis, which occurs when an individual body attacks itself and leads to damage of the joints. It results in inconsequential joint destruction and a long-lasting as well as difficult to eradicate debilitation. The images below are pictures of the skeleton infected with arthritis.

The bone loss in rheumatoid arthritis results in several cellular and biochemical events that are in hand with the remodeling of an individual’s body skeleton. In the life processes and it6her activities, the human skeleton is usually in a dynamic state of various processes of improvement. During these processes of remodeling, the discrete packets of bone, often known as the primary multicellular units, get reabsorbed back as other new and fresh bones get formed to take charge of the reabsorbed matrix. At times, these processes fail to lead to a failed or malfunctioning mechanism hence the local micro-damage to the skeleton and the collapse in the adaptation to changing biochemical factors (Moreland & Emery, 2003).

In this mechanism, there is the erosion of the focal bone, and juxta-articular as well as the systematic bone loss in rheumatoid arthritis. These involve some regions of the skeleton, and the primary factor of these patterns of bone loss is due to the active disequilibrium towards the rate at which bone resorption takes place. Another major factor is the formation that doesn’t rely on either of the cellular and pathological occurrences, of which they all get reversed and non-reliance on the mechanism of arthritis.

The focal bone loss in arthritis gets brought about by the mechanism of the bone-pannus junction and subchondral bone marrow. In this particular arrangement, there occur the resorption lacunae of the multinucleated cells, which play the role of expressing the general mechanism of the repertoire of the already matured and ready osteoclasts. These involve the availability of the phosphates acid that are more resistant and the cathepsin K mechanism as well as the activity involving the expression of a failed m- ribonucleic acid receptor. Therefore in these sites, the mechanism generates a failure in the resorption of the focal bone as well as another role of authentic osteoclasts (Moreland & Emery, 2003).

 The mechanism further diminishes the synovial tissues, eroding the cells of the macrophage lineage. Therefore, appropriate stimuli fail to get introduced to give the existing differences in pre osteoclasts therefore leading to a failure in the functioning of the osteoclasts. Since the synovial tissue gets enriched with sources of various cytokines and inflammatory mediators, they are necessary for the induction of recruitment, differentiating as well as activating the osteoclasts. Since they get malfunctioned by the whole mechanism, they end up unable to perform the hiring, differentiation function as well as activation of the osteoclasts.