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Pharmacology Population - Assignment Example

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The author of the assignment concludes that population pk plays very significant and contributing role in pharmacology. This is because it is through population pk that populations of patients are differentiated based on their unique characteristics…
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Download file to see previous pages In a study by Bartelink, Rademaker, Schobben, et al. (2006), population pk was found to be a very important approach through which not just pharmacokinetic information is obtained from sparse data sets but also pharmacodynamic information obtained from this same sparse data set. Leeder (2004) also observed that there stages in the drug development process where the very large population may be needed but with only a few observations per patient so as to determine the exact and unique differences with drug behavior in each patient based on special characteristics. To achieve this, population pk is employed or used to obtain information at both the phase II and phase III clinical trials among patients. It is not surprising that Ernest, Elder, Martini, et al. (2007) identified population pk as a practice associated with several pharmaceutical companies in the course of their drug development process. Certainly, population pk comes as a single most reliable mechanism by which dosage determination to drugs can be done due to the size of the population used in the sparse data sets, each of whom is observed for very specific outcomes based on their demographic and pathophysiology characteristics.
Also writing on the contribution of population pk to drug development, Roosmarijn et al. (2011) found that there are instances when intensive blood sampling can be attained. Meanwhile, Hsieh and Korfmacher (2006) noted that where intensive blood sampling is possible, there is the benefit of replicating the outcomes with particular blood samples for a larger population size. This means that where intensive blood sampling is not possible an alternative is needed to ensure that almost all populations are catered for. Typical situations in drug development where intensive blood sampling has not been attainable include drug development processes for children, cancer, and AIDS. ...Download file to see next pages Read More
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