Diacylglycerol in Nephron - Research Paper Example

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The present study discusses DAG in nephrons. Physiological Variable: Measured and compared with rapeseed oil (GRAS Status of DAG, 21).Mechanism of Control: Formation of endocannabinoid 2-arachidonoyl-sn-glycerol by hydrolysis of 1,2-diacyl-sn-glycerol (DAG), and catalyzed by DAG (Jung et al, 60-67)…
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Diacylglycerol in Nephron
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Cell Signaling Pathway: Three pathways of phosphatidylcholine metabolism lead to DAG generation, catalyzed by PC specific phospholipase, PC-specific phospholipase D and phosphatidic acid phosphatase (PAP) activation, and conversion of ceramide into sphingomyelin (SM) catalyzed by PC ceramide choline phosphotransferase respectively (Carbon & Lopez-Sanchez, 917).

Changes in Cell Signaling Pathway with Age: With age, the diminishing DAG levels enable its action as an attenuator of the PKC system (Nogaroli et al, 80).
Pathophysiology Due to a Problem with the Signaling Pathway: Activation of the DAG-protein kinase C (PKC) pathway is a recognized characteristic of diabetes. “PKC is an important intracellular pathway that can be activated by many of the metabolic and hemodynamic factors involved in the pathogenesis of diabetic nephropathy” (Schrijvers, Vriese & Flyvbjerg, 971). 

Conclusion: From the above study it can be concluded that DAG has a significant role in nephrons and need to be studied in details to understand its functioning. Read More
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