StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...

Epidemiology, Diagnosis, and Treatment of Melanoma - Assignment Example

Comments (0) Cite this document
Summary
The author focuses on melanoma which is defined as a malignant tumor that originates from a melanocyte, a specialized type of cell containing the pigment melanin. Although the vast majority of melanomas are found in the skin, they are also seen in the eye and the bowel. …
Download full paper File format: .doc, available for editing
GRAB THE BEST PAPER94.2% of users find it useful
Epidemiology, Diagnosis, and Treatment of Melanoma
Read Text Preview

Extract of sample "Epidemiology, Diagnosis, and Treatment of Melanoma"

Download file to see previous pages Exposure to ultraviolet rays (UVA & UVB) rank as the most important factors for the development of melanomas. This effected through DNA damage, specifically thymine dimerization leading to oncogenic mutations. It is well known that the incidence of melanoma in Queensland, Australia (50/100,000) is five times that of the UK (10,000), despite the fact that the nearly all cases in Australia occur in people of Scottish and Irish descent. This clearly points out to solar exposure as the prime factor in its causation. Although tanning beds (Berwick 507) and sunscreens have been implicated as a possible causative factor, no significant statistical evidence has been presented yet. The additional risk is also seen in red-headed and fair-skinned people, people with multiple dysplastic or atypical naevi, and in a condition called congenital giant melanocytic naevi.
1. Germline Mutations: Apart from the fact that melanoma clusters can be seen in certain families, and melanoma-prone families are well known to have mutations in CDKN2A, CDK4, and other genes. The p16 gene mutation has also been reported in over 25% of familial melanomas worldwide, as well as in about 10 % of sporadic melanomas. It has a low degree of penetrance, and it is likely that sporadic melanoma has a complex pattern of inheritance.
Melanoma also has an association with various cancer family syndromes, most notably pancreatic cancer, but also in breast, throat and gastrointestinal cancers.
2. Somatic mutations: A genetic progression model of the step-by-step transformation of precursor lesions (naevi) to melanomas or the stages of melanoma progression itself have shown that there are important genetic loci where were changes accumulate. They are mostly due to loss of chromosomal material on multiple loci: chromosomes 1,3,6,9,10,11 and 17 being particularly affected. Somatic mutations on the BRAF gene has also been described in up to 60 % of melanomas.  ...Download file to see next pages Read More
Cite this document
  • APA
  • MLA
  • CHICAGO
(Epidemiology, Diagnosis, and Treatment of Melanoma Assignment, n.d.)
Epidemiology, Diagnosis, and Treatment of Melanoma Assignment. Retrieved from https://studentshare.org/medical-science/1524977-melanoma
(Epidemiology, Diagnosis, and Treatment of Melanoma Assignment)
Epidemiology, Diagnosis, and Treatment of Melanoma Assignment. https://studentshare.org/medical-science/1524977-melanoma.
“Epidemiology, Diagnosis, and Treatment of Melanoma Assignment”, n.d. https://studentshare.org/medical-science/1524977-melanoma.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Epidemiology, Diagnosis, and Treatment of Melanoma

Diagnosis and Treatment

...? Diagnosis and Treatment Introduction: There are different categories of psychological disorders that include mood, anxiety, dissociative, eating, sleeping, somatoform, personality, adjustment and related other disorders. Mood disorders are particularly associated with the disturbances occurring in the mood of an individual. This in turn affects the emotional condition of the person. One of the common mood disorders include depression that creates sadness in the individual reflected through disturbed symptoms in the individual (Psychological Disorders, pp.490-492). The present study focuses on the mood disorder of depression and makes a study on its nature, its current trend of diagnosis, and treatment available for the disorder. Mood...
3 Pages (750 words) Assignment

Diagnosis and Treatment Recommendations

...? Running Head: DIAGNOSIS AND TREATMENT RECOMMENDATIONS With respect to the case study report, the male client in named Blackwell is experiencing a substance abuse related problem in his life. He is a separated father with three children, who are currently living with their mother. The reason for separation derives its roots from Blackwell’s habitual substance abuse problem within the household setting. Apart from the family breakup, Blackwell has lost employment contracts on several occasions because of drinking related behavior. Consequently, the client is going through a tough journey on social and psychological complications associated with excessive substance abuse. From information contained in the case study report, Blackwell...
5 Pages (1250 words) Research Paper

Diagnosis And Treatment Of Melanoma

...Diagnosis And Treatment Of Melanoma Melanoma bears the dubious distinction of being the most well-known and deadly form of skin cancer. Due to the fact that this particular form of skin cancer is so deadly (ultimately claiming the lives of between 7,000 to 12,000 individuals annually) this brief analysis will seek to provide an overview and discussion of key facts and statistics that are concentric upon the rate and exhibition of melanoma skin cancer throughout society. It is the hope of this author that such a level of explanation the discussion will be beneficial to the reader, and to the researcher, in terms of helping to understand this particular disease to a better and more effective degree. Ultimately, even though melanoma...
6 Pages (1500 words) Essay

Are Social Timing Deficits More Pronounced In People With Atypical Diagnosis Of Autism

It is a severe developmental disorder that affects the way a child sees and interacts with the rest of the world. It limits their ability to interact with others socially and most of the times try to avoid human contact. It is also a part of a large group of disorders called pervasive developmental disorders (PDD) (Autism-PDD.net, 2005).

In 1908, Eugen Bleuler a Swiss psychiatrist coined the word "autism" in schizophrenic patients who screened themselves off and were self-absorbed. Leo Kanner while at Johns Hopkins first identified autism in 1943 when he described 11 self-absorbed children who had following common traits: impairments in social interaction anguish for changes, good memory, belated echolalia, over se...
11 Pages (2750 words) Case Study

Autoimmune Diseases and the Importance of Their Treatment in the Modern Society

The research should be considered as the basis (from a theory and practice perspective) of immunology as it is known today. During the years that followed the above studies, immunology was developed furthermore and many theories were stated while the methods of treatment were differentiated in order to respond to the changing living standards and styles of life. The main reason for the choice of the particular topic has been its importance for patients that suffer from one of the types of the particular disease. In fact, a study published in the Environmental Health Perspective (2003, 483) proved that “autoimmune diseases are chronic, potentially life-threatening conditions; there are more than 80 recognized autoimmune disea...
10 Pages (2500 words) Case Study

The Diagnosis and Treatment of Disease Outline: The Roles of the Imaging and Treatment Modalities

Dramatic developments in the field of science and technology have provided newer and enhanced diagnostic tools to make arrive at a more precise diagnosis on one side and on the other side given new meaning to the traditional treatment modalities, as well as creating new treatment modalities. 

Peering inside the human body for a better understanding of any abnormalities within that are the cause for illness in a patient had remained an unrealized need until the advent of the x-ray imaging technique. Since then advances in the x-ray imaging techniques have led to new imaging modalities to remove the inadequacies that were experienced through the use of mere x-rays. Fluoroscopy is one such development in imaging modal...
7 Pages (1750 words) Term Paper

Counseling and Methadone in Treatment of Substance Abuse

Substance abuse, including tobacco use and nicotine addiction, is associated with a wide range of serious health and social problems. Recent epidemiological evidence demonstrates that 72 conditions requiring inpatient treatment are wholly or partially attributable to substance abuse. Consequently, the estimated annual cost for health care, law enforcement, motor vehicle crashes, crime, and lost productivity due to substance abuse is nearly 1 thousand dollars for every American citizen, including children (Austin, 2005). Such a disturbing situation with substance abuse can not but appeal for immediate and effective actions from the government and local authorities.

Although the problem is not new, the search for the most...
10 Pages (2500 words) Term Paper

Community Assessment for Treatment and Prevention of Hepatitis C in Adult Population

With the increased awareness and advancement in research, involving human immunodeficiency virus (HIV) epidemic, clinical expertise exists for the prevention and management of chronic viral diseases like HCV among injection drug users, since the mode of infection and behavior of vulnerable population for both HIV and HCV contagion are identical. Since the transmission of HCV is similar to HIV and IDU is the primary risk factor for HCV infection, and coinfection of these two blood-borne diseases cause morbidity and mortality, harm reduction approach and the strategies that address the social and economic harms that impact an individual, community, or society are paramount in preventing the epidemic.

Hepatitis C is the ma...
11 Pages (2750 words) Term Paper

Ryanairs Staff Treatment and Motivation Problems

To prove that not all of the public accusations against the way Ryanair handles its employees is true; a combination of qualitative and quantitative research methods will be utilized using research survey questionnaires. Aiming to strengthen the research survey results, an interview with Ryanair’s human resource assistant manager, customer service supervisor, duty manager, and duty controller was conducted to enable the researcher to gain a better insight with regards to employees’ views on labor unions and the type of motivational strategies used by the company.
Ryanair is an Irish low-cost airline with its head office in Dublin and its main operational base at London Stansted Airport. It is Europes major low-cos...
43 Pages (10750 words) Dissertation

Treatment of Congenital Deformities of the Talip

Clubfoot is rarely detected in ultrasonography before the 16th week of gestation. Four types of talipes have been identified. The most common one being talipes equine varus, commonly known as clubfoot. In this condition, the foot points down and twists inwards at the ankle joint. The other three forms of talipes are less common and are known as talipes equanovalgus in which the footpoints out and down, talipes calcanovarus in which the foot points inwards and up, and talipes calcanovalgus in which the foot points inwards and down.

Talipes is a complicated condition and its management depends on the degree of rigidity, associated abnormalities and secondary muscular changes (Morcuende et al 2006) In the UK, prior to 2001...
8 Pages (2000 words) Assignment

Epidemiology of Avian Influenza, and Pandemic Preparedness Strategies

The Asian Flu claimed 70,000 people’s lives in 1957. The Hong Kong Flu in 1968 killed 34, 000 people (Howard, 2007). These previous occurrences have made world and community leaders as well as the public fearful of a threat of a pandemic. The Avian flu virus is a type A influenza virus. Type A influenza viruses can be found in humans, birds, and other mammals. It is the only type of influenza virus that has caused pandemics as evidenced by history (Beigel, 2008).

Only four known strains of avian influenza viruses have been found to affect humans among them H5N1, H7N3, H7N7, and H9N2. Among the four, H5N1 is the most highly pathogenic. It is the greatest source of alarm due to two primary reasons. The first reason...
7 Pages (1750 words) Report

Science in Public Health - Epidemiology

On the other hand, the subjects in cohort studies are selected on the basis of whether they have a certain risk factor/exposure or not and are then followed over time to observe for the development of the outcome/disease (Mann, 2003). Cohort studies can either be prospective or retrospective and can be used to calculate the incidence of a disease and the relative risk of developing a disease.
As compared to observational studies, such as case-control and cohort studies, in interventional studies such as a randomised control trial, the investigator assigns the exposure. In other words, the investigators introduce an intervention and the study objective is to determine the effect of that intervention on the study population. Such...
7 Pages (1750 words) Assignment

Various Treatment of Young People in the Criminal Justice System

The ways in which the treatment of young offenders is differentiated from that of adult offenders are also presented using appropriate literature; particular reference is made to the role of Young Offender Institutions (YOI). It is proved that the current criminal justice for young offenders in the UK is not effective, despite the measures taken by the government for securing the rehabilitation of these individuals. On the other hand, the full alignment of the treatment of young offenders with that of the adult offenders, as this practice is in progress in the UK, will not resolve the problems related to the rehabilitation of young offenders. The alteration of the rules of the existing criminal justice system without eliminating t...
7 Pages (1750 words) Coursework
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Assignment on topic Epidemiology, Diagnosis, and Treatment of Melanoma for FREE!

Contact Us