Biomarkers Associated with P53 in Breast Cancer - Book Report/Review Example

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Summary

This study "Biomarkers Associated with P53 in Breast Cancer" shows that few biomarkers have been found to have utility for breast cancer diagnosis and prognosis. Therefore, continued efforts are greatly needed for new biomarkers that will be useful for breast cancer…

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Biomarkers Associated with P53 in Breast Cancer

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Subject: Human Resources
Type: Book Report/Review
Level: Business School
Pages: 2 (500 words)
Downloads: 2
Author: uniquehane

Extract of sample "Biomarkers Associated with P53 in Breast Cancer"

Disruption of p53 function bears a central role in carcinogenesis. P53 gene changes have happened before breast cancer development and thus might influence the peril of cancer peril. This necessitates looking at an unexplored aspect of biomarkers associated with p53 status in breast cancer. The main aim of this study was to find biomarkers associated with P53 status in Breast Cancer; Mutant or Wild Type, and how the status influences a biomarker's pathways.

Data were obtained from the array express. The sample of 312 female patients with breast cancer tissues was available for analysis. The criteria for entrance to the project were T1-3 breast cancer having Mo-status. The data was validated using A PCR data validation technique whereby cDNA is synthesized using mRNA molecules available in the sample that is then amplified exponentially by a combination of gene-particular primers, the DNA polymerase enzyme, and labeled nucleotides, hypothetically doubling the cDNA amount at each cycle (Rohan1, et al., 2006). The data was then processed through microarray analysis and ANN. The findings were visualized through Cytoscape.

Biomarkers associated with p53 status include the following: p53K373ac, P53 K386ac, hMOF, H3K9me3, SUV39H1, and H3K9me3. Both the cluster biomarkers and non-cluster biomarkers have also been found to be associated with favorable results of a patient in Kaplan-Meier survival analysis. Other biomarkers associated with p53 status include histone variant H2A.Z as well as its hyperacetylated form of H2A. Z that is correlated with the status of Estrogen Receptor of the tumors, which is consistent with a report which the gene encoding this histone variation is estrogen-regulated. The biomarkers associated with p53 status in breast cancer have the potential for finding reliable solutions in the diagnosis and treatment of breast cancer.

Conclusion
Biomarkers associated with p53 status in breast cancer have the potential of enhancing the diagnosis and treatment of breast cancer. These biomarkers include p53K373ac, P53 K386ac, MOF, H3K9me3, SUV39H1, and H3K9me3. Both the cluster biomarkers and non-cluster biomarkers have also been found to be associated with favorable results of a patient in Kaplan-Meier survival analysis. Other biomarkers associated with p53 status include histone variant H2A.Z as well as its hyperacetylated form of H2A.Z that is correlated with the status of Estrogen Receptor of the tumors, and which is consistent with a report which the gene encoding the histone variation is estrogen-regulated.

The development, in this case, calls for more focus on p53 status both mutant type and wild type. The p53 exists in the breast before the development of tumors and in its functioning, it aids in the development of the tumors. Alterations or changes in the structure of p53 result in patient outcomes useful in improving diagnosis and treatment of breast cancer thereby reducing morbidity and mortality from the diseases, especially among women (Rohan1, et al., 2006). These biomarkers are useful for the detection of breast cancer. Read More

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