An Observational Study of an Outcome of an Aneurysmal Subarachnoid Haemorrhage - Research Paper Example

Aneurysmal Subarachnoid haemorrhage (aSAH) is one of the most feared neurological diseases and comprises 1% to 7%(Feigin et al., 2005) of all strokes, causing death and dependence in approximately 40%-70% of patients(Navarro, 2007). The Cerebral vasospasm is the most common devastating complication of aneurysmal subarachnoid haemorrhage (aSAH), that frequently leads to the subsequent development of Delayed Cerebral Ischemia (DCI) in 33%-38% of patients following aSAH causing to severe morbidity and mortality (de Rooij, Rinkel, Dankbaar & Frijns, 2012; Haley, Kassell, Apperson-Hansen, Maile, & Alves, 1997; Lanzino et al., 1999). Predicting which patients with aSAH will develop DCI due to cerebral vasospasm remains a challenge. Early Recognition and prevention of DCI is the key to better outcome of SAH. Cases are defined as angiographically –proven aneurysmal subarchanoid haemorrhage.

The retrospective medical notes, for demographic , clinical parameters and the GOS (Glasgow outcome score) and MRS(Modified Ranking Score) during the discharge and at >1Month data were reviewed of all patients admitted with aSAH to the National Hospital for Neurology and Neurosurgery (NHNN) and across other sites within the UK Stroke Research Network, from year 1987 to 2011. The predictive value of admission characteristics were tested using multivariate logistic regression models to determine factors independently associated with DCI.

Results: Among the 1820 patients, there were 152 DCI. Overall, the occurrence of DCI is 8.4% and was a higher incidence of DCI in females (OR, 0.75 (95% CI 0.50 to 1.13); p=0.16). Aneurysmal Subarachnoid haemorrhage (aSAH) is one of the most feared neurological diseases and comprises 1% to 7%(Feigin et al., 2005) of all strokes, causing death in and dependence in approximately 40%-70% of patients(Navarro, 2007)The annual incidence of SAH has been estimated to range from 7 to 10 per 100,000 person-years and comprises 1% to 7% of all strokes. The incidence seems to be relatively stable over the time(30 years) and in various countries, except for Finland and Japan , where incidence seems to be higher.