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The Impact of the Clients Biochemical Results - Assignment Example

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The following paper under the title 'The Impact of the Client’s Biochemical Results' concerns the biochemistry results which reveal hyponatremia, hypokalemia, and hypochloremia. This indicates that there is an electrolyte imbalance caused by diarrhea…
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The Impact of the Clients Biochemical Results
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Download file to see previous pages A study by Boehme, Autschbach, Raeth, 2007 showed that in patients with diabetes mellitus, there is a high prevalence of severe acute gastric inflammation or ulcer disease. Raised levels of C-reactive-protein or blood leukocyte counts in such patients indicate a diagnostic endoscopy.
Metformin is a biguanide oral antidiabetic drug. It is completely absorbed from the gastrointestinal tract within 6 hours of ingestion (Scheen, 1996). It is rapidly distributed following absorption and does not bind to plasma proteins. There is no liver metabolism (Scheen, 1996). Metformin undergoes renal excretion and has a mean plasma elimination half-life of between 4.0 and 8.7 hours (Scheen, 1996.)
Simvastatin belongs to the statin group of drugs. It is used to control hypercholesterolemia and to prevent cardiovascular disease. Following an oral dose of simvastatin, 13% is excreted in urine, and 60% in feces (Laurence & Bennet, 1992.) Plasma concentrations peaks at 4 hours. Simvastatin undergoes extensive first-pass extraction in the liver, and thus there is low availability of the drug in the general circulation (Laurence & Bennet, 1992.)
Aspirin is an NSAID and has analgesic and antipyretic activities. It is well absorbed from the stomach and upper intestinal tract. Hydrolysis removes the acetyl group and the resulting salicylate ion is inactivated by conjugation with glycine. At therapeutic doses, this reaction proceeds with a t1/2 of 4 hours. Steady plasma concentration can be maintained if given 6-hourly (Laurence & Bennet, 1992.)
Atenolol is a beta1-selective (cardioselective) beta-adrenergic receptor blocking agent. Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces (Laurence & Bennet, 1992). Peak blood levels are reached between 2-4 hours after ingestion. It undergoes little or no metabolism by the liver, and the absorbed portion is eliminated primarily by the kidneys. ...Download file to see next pagesRead More
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